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Spécifications
- Antibody type:Primary
- Antigen name:TANK-binding kinase 1
- Clonality:Monoclonal
- Clone:108A429
- Gene ID:29110
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Antigen symbol:TBK1
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:50 μg
- Western blot:Yes
- Antigen synonyms:TBK1|Serine/threonine-protein kinase TBK1|NAK|NF-kappa-B-activating kinase|TANK-binding kinase 1|T2K
- Storage buffer:Preservative: 0.02% Sodium Azide; Constituents: PBS
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:0.5 mg/ml
- Immunogen:Full length protein (Human).
- Tested applications:ICC/IF, IHC, WB
- Purification:Protein G purified
- Cat. no.:89359-180
- Supplier No.:GTX12116
Spécifications
A propos de cet article
Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. Phosphorylation of I-kB by IkB kinase (IKK) complex leads to degradation of I-kB and activation of NF-kB. The IKK complex contains IKKa,IKKb, and IKKg. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-kB-activating kinase), and T2K. NAK/TBK1 activates IKKb through direct phosphorylation. NAK/TBK1is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
WB: Use at a concentration of 1 - 2 ?g/ml. Detects a band of approximately 80 kDa (predicted molecular weight: 87.5 kDa). For optimal results, primary antibody incubations should be performed at room temperature.ICC/IF,IHC:Use at an dependent assay. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: TBK1
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human