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Spécifications
- Antibody type:Primary
- Antigen name:Coagulation Factor 12
- Clonality:Monoclonal
- Clone:C6B7
- Gene ID:2161
- Host:Mouse
- Isotype:IgG1
- Neutralisation:Yes
- Reactivity:Human
- Antigen symbol:F12
- Conjugation:Unconjugated
- ELISA:Yes
- Size:125 μg
- Epitope:Light Chain
- Antigen synonyms:HAF|Coagulation Factor XII|HAE3|Hageman Factor|HAEX
- Storage buffer:PBS, pH7.2
- Storage temperature:Upon receipt - Keep as concentrated solution. Aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:3.5 mg/ml
- Immunogen:Purified human Factor XII.
- Tested applications:ELISA, Neut
- Purification:Protein G purified
- Cat. no.:89360-950
- Supplier No.:GTX21008
Spécifications
A propos de cet article
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq]
Dilute in PBS or medium which is identical to that used in the assay system. At 100 nM, this antibody inhibits 50% of Factor XII activity. This antibody can also be used in a coagulation assay
Type: Primary
Antigen: F12
Clonality: Monoclonal
Clone: C6B7
Conjugation: Unconjugated
Epitope: Light Chain
Host: Mouse
Isotype: IgG1
Reactivity: Human