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Spécifications
- Antibody type:Primary
- Antigen name:B-cell activating factor
- Clonality:Monoclonal
- Clone:Buffy-1
- Gene ID:10673
- Host:Rat
- Isotype:IgG2a
- Reactivity:Human
- Antigen symbol:BAFF
- Conjugation:Unconjugated
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:50 μg
- Western blot:Yes
- Antigen synonyms:CD257|ZTNF4|THANK|TALL-1|TNFSF20|DTL|TNFSF13B|TALL1|TNLG7A|BLYS
- Storage buffer:Preservative: 0.02% Sodium Azide; Constituents: PBS
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:1 mg/ml
- Immunogen:Recombinant soluble fragment, corresponding to amino acids 83-285 of Human BAFF.
- Tested applications:Fluorescence-Activated Cell Sorting
- Purification:>95% by SDS-PAGE
- Cat. no.:89360-168
- Supplier No.:GTX16107
Spécifications
A propos de cet article
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL1 (for TNF- and ApoL- related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NFkB and c-jun N-terminal Kinase). BAFF/BLyS was characterized as a B cell stimulator since it induced B cell proliferation and immunoglobulin secretion. Two receptors for BAFF were recently identified and designated TACI and BCMA. BAFF and its receptors are involved in the development of systemic lupus erythaematosus and other B cell associated autoimmune diseases. Like TNFa and TRAIL,THANK was shown to activate NF-kB and c-jun N terminal kinase (JNK) and to induce apoptosis.
FACS: Use at a concentration of 0.5-5 ?g/ml. ICC: Use at an assay dependent dilution. WB: Use at a concentration of 1 ?g/ml. Predicted molecular weight: 31 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: BAFF
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG2a
Reactivity: Human