Recombinant Proteins Upstream Processing
Using microbial fermentation for the development and manufacture of recombinant proteins keeps on showing advantages, e.g., for the expression of proteins that do not require post-translational modifications - as microbial systems, such as E. coli, lack post-translational mechanics.
How Avantor® products support upstream processing
The Avantor portfolio addresses the needs in fermentation media and supplements. Our fermentation products support cell growth and productivity, while meeting the required quality and performance parameters that allow for seamless transfer from R&D, all the way through pilot scale and on to manufacturing scale.
Centrifuges and reagents required for primary recovery, concentration and clarification are available. Once your optimal in-house developed production-based medium is determined, look to Avantor to custom manufacture your medium in liquid or dry formats and package them to allow efficient transfer to your bioreactor.
Depending on your expression system (e.g., microbial, mammalian, yeast, or insect), maintaining cell viability is critical during applications – starting with modifications of the cell of interest, through process development and scale-up, clinical trials, and finally commercial manufacturing.
Culture media formulation development is not mutually exclusive of the methods for clone selection or the processes used (bioreactor and cells) to achieve the desired cell density and productivity. Our broad offering of media, growth supplements, and complimentary products (e.g., dissociation enzymes, selection antibiotics, and various plasticware) can be provided in configurations that support bench scale-up to full production needs.
We provide the building blocks that allow you to develop and optimize culture formulations specific to the cells you are using. Our approach allows you to design in-house, culture media specific to your cell type, as an alternative to commercial pre-design formulations, giving you complete control over your processes.
Avantor’s J.T.Baker® brand offers the only cGMP manufactured IPTG to ICHQ7 standards
That provides biopharma researchers and manufacturers with a solution to help scale recombinant proteins from research and development to clinical and full-scale manufacturing with speed, quality, and confidence.
Explore solutions for upstream processing of recombinant proteins
Discover Avantor's fluid handling solutions and access literature, technical articles and videos.
Improve your production process with Avantor’s cGMP and cGDP-supported chemicals and excipients.
Avantor’s environmental control solutions provide customized support for exactly how your facility operates.
Product choices for discovery, product development & pre-clinical
Product choices for scale-up & production
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