576 Results for: "trans-4-phenylcyclohexanecarboxylic acid"

Supplier: Biotium

This MAb recognizes a protein of 134 kDa, which binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils). Fucosylation is essential for binding to E-selectin. It contains sialic acid residues and 16 Cys-rich GLG1 repeats. This MAb can be used to stain the Golgi complex in cell or tissue preparations and can be used as a Golgi marker in subcellular fractions. It produces a diffuse staining pattern of the Golgi zone in normal and malignant cells. This MAb is an excellent marker for human cells in xenographic model research. It reacts specifically with human cells. The Golgi apparatus is an organelle present in all eukaryotic cells that forms a part of the endomembrane system. The primary function of the Golgi apparatus is to process and package macromolecules synthesized by the cell for exocytosis or use within the cell. The Golgi is made up of a stack of flattened, membrane-bound sacs known as cisternae, with three functional regions: the cis face, medial region and trans face. Each region consists of various enzymes that selectively modify the macromolecules passing though them, depending on where they are destined to reside. Several spherical vesicles that have budded off of the Golgi are present surrounding the main cisternae. The Golgi tends to be more pronounced and numerous in cells that make and secrete many substances such as plasma B cells.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: G-Biosciences

Succinimidyl 4-(N-maleimidomethyl) cyclohexane-1-carboxylate Heterobifunctional Cross Linkers.

Supplier: Prosci

Serine/threonine-protein kinase that converts transient diacylglycerol
(DAG) signals into prolonged physiological effects downstream of PKC, and is involved in
the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and
trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation
by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling,
and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced
apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal
growth factor receptor (EGFR) on dual threonine residues, which leads to the
suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and
subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3
proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding
to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the
heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural
integrity of the Golgi membranes, and is required for protein transport along the
secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport
vesicles that are on their way to the plasma membrane. May act by activating the lipid
kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of
phosphorylated inositol lipids, which induces a sequential production of DAG,
phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and
generation of specific transport carriers to the cell surface. Under oxidative stress, is
phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK
complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell
migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment
in newly forming focal adhesion.

Supplier: Thermo Scientific

This antibody is predicted to react with bovine, mouse and rat based on sequence homology. This gene belongs to a group of vacuolar protein sorting genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex.

Supplier: Thermo Scientific

RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.

Supplier: Thermo Scientific

This antibody is predicted to react with canine, mouse and rat based on sequence homology. This gene belongs to a group of vacuolar protein sorting genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene.

Supplier: Thermo Scientific

This antibody is predicted to react with bovine, mouse, porcine and rat based on sequence homology. This gene belongs to a group of vacuolar protein sorting genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.

Supplier: Thermo Scientific

RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.

Supplier: Thermo Scientific

This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. This gene belongs to a group of vacuolar protein sorting genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms, and usage of multiple polyadenylation sites have been found for this gene.

Supplier: Thermo Scientific

This gene encodes a member of the sorting nexin family. Members of this family contain a phox domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 gene.

Supplier: Thermo Scientific Chemicals

Diethyl fumarate 98%

Supplier: TCI America

CAS Number: 100707-54-8
Molecular Formula: C8H15NO2
Molecular Weight: 193.67
Purity/Analysis Method: >98.0% (N,T)
Form: Crystal

Supplier: AGILENT TECHNOLOGIES, INC (CSD) CA

A bonded, crosslinked cyanopropylphenyl phase column that operates from 40 to 240 °C and is excellent for FAME separations.

Supplier: Thermo Scientific

This antibody is predicted to react with mouse and rat based on sequence homology. RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.

Supplier: Thermo Scientific Chemicals

MDL: MFCD00004386 Beilstein Registry No.: 2209732

Supplier: Thermo Scientific

Thermo Scientific Pierce SMCC is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7–9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5–7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group, but will slowly hydrolyze and lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2–7.5, with the NHS ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.

Supplier: Thermo Scientific

This antibody is predicted to react with mouse based on sequence homology. TIP47 (tail-interacting protein 47) is a member of PAT family of proteins (perilipin, ADRP, S3-12 and OXPAT) which plays a key role in the packaging/storage of neutral lipids and is required for mannose 6-phosphate receptors (M6PR) transport from endosomes to trans-Golgi network (TGN). TIP47 localizes in cytoplasm, endosome membrane as peripheral membrane protein towards cytoplasmic side, core of lipid bodies/ lipid droplet, in lipid sails and in the envelope, and it interacts with M6PR, IGF2R etc. via the cytoplasmic domain. As a cargo protein, TIP47 facilitates the delivery of M6PR from endosomes to TGN where it binds to cytoplasmic domains of cation-independent/-dependent M6PR and translocates to late endosomes by binding to Rab9 GTPase. Like other PAT family members, TIP47 associates with lipid droplets and influence insulin signaling as evidenced by combined knockout of ADRP /TIP47 leading to decreased insulin sensitivity. During HIV-1 infection, TIP47 acts as a cellular cofactor playing a part in Env incorporation, allowing the encounter and physical association between HIV-1 Gag and Env proteins during viral assembly process. TIP47 is identical to pregnancy-related placental tissue protein 17b (PP17b) and is overexpressed in cervical carcinoma patients wherein it is considered a serum tumor marker.

Supplier: TCI America

CAS Number: 7780-06-5
MDL Number: MFCD00048292
Molecular Formula: C12H14O2
Molecular Weight: 190.24
Purity/Analysis Method: >98.0% (GC)
Form: Clear Liquid
Boiling point (°C): 270
Flash Point (°C): 110
Specific Gravity (20/20): 1.03

Supplier: TCI America

Trans-4-Acetoxycinnamic Acid, Purity: >98.0%(GC)(T), Cas no: 27542-85-4, MF: C11H10O4 / 206.20, Physical state: , Form: , Synonyms: trans-3-(4-Acetoxyphenyl)-2-propenoic Acid, Size: 5G

Supplier: TCI America

4-(trans-4-Pentylcyclohexyl)phenylboronic Acid, CAS Number: 143651-26-7, Molecular Formula: C17H27BO2, Molecular Weight: 274.21, Synonyms: 4-(trans-4-Pentylcyclohexyl)benzeneboronic Acid, Size: 5G

Supplier: TCI America

Trans,Trans-4'-Ethylbicyclohexyl-4-Carboxylic Acid, Purity: >98.0%(GC)(T), Cas no: 84976-67-0, Molecular formula : C15H26O2, Molecular weight : 238.37, Synonyms: trans-4-(trans-4-Ethylcyclohexyl)cyclohexanecarboxylic Acid, Size: 5G

Supplier: TCI America

4-(trans-4-Ethylcyclohexyl)benzoic Acid, Purity: >98.0%(GC)(T), CAS Number: 87592-41-4, Molecular Formula: C15H20O2, Molecular Weight: 232.32, form: Crystal- Powder, Color: White - Almost white, Size: 5G

Supplier: TCI America

Trans-4-Acetoxycinnamic Acid, Purity: >98.0%(GC)(T), Cas no: 27542-85-4, MF: C11H10O4 / 206.20, Physical state: , Form: , Synonyms: trans-3-(4-Acetoxyphenyl)-2-propenoic Acid, Size: 25G

Supplier: TCI America

4-(trans-4-Propylcyclohexyl)benzoic Acid, Purity: >98.0%(GC)(T), CAS Number: 65355-29-5, Molecular Formula: C16H22O2, Molecular Weight: 246.35, Size: 5G

Supplier: TCI America

4-(trans-4-Propylcyclohexyl)benzoic Acid, Purity: >98.0%(GC)(T), CAS Number: 65355-29-5, Molecular Formula: C16H22O2, Molecular Weight: 246.35, Size: 25G

Supplier: TCI America

Cetraxate Hydrochloride, Purity: >98.0%(HPLC)(T), CAS Number: 27724-96-5, Molecular Formula: C17H23NO4.HCl, Molecular Weight: 341.83, Synonyms: 3-[4-[[trans-4-(Aminomethyl)cyclohexyl]carbonyloxy]phenyl]propanoic Acid Hydrochloride, Size: 50MG

Supplier: TCI America

Diethyl trans-1,2-Cyclopropanedicarboxylate, Purity: >96.0%(GC), CAS Number: 3999-55-1, MF: C9H14O, MW: 186.21, Synonym: trans-1,2-Cyclopropanedicarboxylic Acid Diethyl Ester, Form: Clear, Liquid, Color: Colorless - Very pale yellow, Size: 1G

Supplier: TCI America

Diethyl trans-1,2-Cyclopropanedicarboxylate, Purity: >96.0%(GC), CAS Number: 3999-55-1, MF: C9H14O, MW: 186.21, Synonym: trans-1,2-Cyclopropanedicarboxylic Acid Diethyl Ester, Form: Clear, Liquid, Color: Colorless - Very pale yellow, Size: 5G

Supplier: MilliporeSigma

( [LXA; 5(S),6(R),15(S)-trihydroxyeicosa-7-trans-9-trans-11-cis-13-trans-tetraenoic acid]). In EtOH. Potent inhibitor of cytotoxic activity of human natural killer cells; shown to be as potent as LTB4 in stimulating human neutrophils to generate superoxides.

Supplier: MilliporeSigma

( [LTB4; 5(S),12(R)-dihydroxy-6-cis-8-trans-10-trans-14-cis-eicosatetraenoic acid] ). In EtOH.