2306 Results for: "small 200"

Supplier: Cytiva

Tricorn empty columns are for high resolution small-scale chromatography at pressures up to 50 bar (Tricorn 10) or 100 (Tricorn 5).

Supplier: Enzo Life Sciences

α-Crystallins composed of αA (~19 kDa) and αB (~19.2 kDa) subunits, are major water-soluble proteins accounting for almost 50% of total protein in the mammalian transparent eye lens and they are also found in a variety of other tissues. Alpha-crystallins are also referred to as small heat shock proteins, since they are induced by increased temperature in a variety of organisms. The α-crystallins have sequence homology as well as structural and functional similarities with the small Hsp’s such as Hsp25/27. Most α-crystallins have four common structural and functional features: (i) molecular weight between 12 and 43kDa; (ii) the formation of large oligomeric complexes composed of αA-crystallin, αB-crystallin and Hsp25/27; (iii) the moderately conserved α-crystallin domain in the central region of the protein; and (iv) molecular chaperone activity. The α-crystallin domain comprises approximately 90 residues, is bounded by variable N-terminal and C-terminal extensions and is involved in oligomer assembly. Oligomers can reach 800 kDa or more and are dynamic, exhibiting subunit exchanges and organizational plasticity, possibly leading to functional diversity. Phosphorylation of serine residues occurs during development and in response to stress, and usually decreases oligomer size. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation. Although productive release and refolding of denatured proteins requires close cooperation with other chaperones. Other proposed functions include a role in membrane stabilization and modulation of intermediate filament organization during physiological stress and neurodegenerative disease. Alpha B Crystallin is phosphorylated on serine 45 by ERK1/2 and serine 59 by MAPKAPK-2. When mono-phosphoylated αB-crystallin is isolated it contains only αB-crystallin phosphorylated at serine 19.

Supplier: Thermo Scientific

This antibody is predicted to react with bovine and canine based on sequence homology. The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13. 1.

Supplier: Cytiva

Superdex prep grade is a preparative gel filtration medium with a composite matrix of dextran and agarose

Supplier: Medicom

Fully textured black nitrile powder-free gloves with superior resistance and grip.

Supplier: Honeywell Safety Products

Comfortable half-mask or full facepiece respirators for use with North Safety Products cartridges and filters.

Supplier: Cytiva

Owing to their extremely high purity our seed testing papers provide reliable and reproducible results. The papers are made from pure cellulose without any additives and do not contain any substances that could influence the growth of the seeds. The constant water absorption of the papers ensures the continuous provision of the required amount of water.

Supplier: IBI Scientific

The miRNA Isolation kits are designed for the purification of microRNA (miRNA) and other small cellular RNAs from tissue samples and cultured cells

Supplier: Bioss

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets. RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1. RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2. MAPK14 interacts also with casein kinase II, leading to its activation through autophosphorylation and further phosphorylation of TP53/p53. In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. In a similar way, MAPK14 phosphorylates the ubiquitin ligase SIAH2, regulating its activity towards EGLN3. MAPK14 may also inhibit the lysosomal degradation pathway of autophagy by interfering with the intracellular trafficking of the transmembrane protein ATG9. Another function of MAPK14 is to regulate the endocytosis of membrane receptors by different mechanisms that impinge on the small GTPase RAB5A. In addition, clathrin-mediated EGFR internalization induced by inflammatory cytokines and UV irradiation depends on MAPK14-mediated phosphorylation of EGFR itself as well as of RAB5A effectors. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Another p38 MAPK substrate is FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates CDC25B and CDC25C which is required for binding to 14-3-3 proteins and leads to initiation of a G2 delay after ultraviolet radiation. Phosphorylates TIAR following DNA damage, releasing TIAR from GADD45A mRNA and preventing mRNA degradation. The p38 MAPKs may also have kinase-independent roles, which are thought to be due to the binding to targets in the absence of phosphorylation. Protein O-Glc-N-acylation catalyzed by the OGT is regulated by MAPK14, and, although OGT does not seem to be phosphorylated by MAPK14, their interaction increases upon MAPK14 activation induced by glucose deprivation. This interaction may regulate OGT activity by recruiting it to specific targets such as neurofilament H, stimulating its O-Glc-N-acylation. Required in mid-fetal development for the growth of embryo-derived blood vessels in the labyrinth layer of the placenta. Also plays an essential role in developmental and stress-induced erythropoiesis, through regulation of EPO gene expression. Isoform MXI2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform EXIP may play a role in the early onset of apoptosis. Phosphorylates S100A9 at 'Thr-113'.

Supplier: Omega Bio-Tek

Achieve fast and reliable purification of DNA or RNA with a relatively small elution volume of 10–15µL

Supplier: New England Biolabs (NEB)

Quickly and easily purify up to 100 µg of high quality total RNA from multiple sample types – all with one kit.

Supplier: Omega Bio-Tek

Omega Bio-tek® provides multiple options for genomic, viral, and mitochondrial DNA extraction from cultured cells, buccal swabs, mouse tail snips, whole blood, buffy coat, and a variety of animal tissue

Supplier: Genetex

Protein extract from Human Small intestine: Jejunum (normal) Pkg Size: 200 ug

Supplier: Genetex

Protein extract from Human Small intestine: Ileum (Liver Cirrhosis) Pkg Size: 200 ug

Supplier: Genetex

Protein extract from Human Small Intestine: Duodenum (Tumor) Pkg Size: 200 ug

Supplier: Agela Technologies

for Small Molecules same as XBP C18 with larger pore size; 150A, 200 m2/g; C%=15

Supplier: Agela Technologies

for Small Molecules same as XBP C18 with larger pore size; 150A, 200 m2/g; C%=15

Supplier: Remco Products

Vikan* Dish Brush with scraper, Color: Orange, Block Material: Polypropylene, Bristle Material: Polyester, Bristle Stiffness: Medium, perfectly for corners, small scraper at the tip to loosen stubborn debris, Width: 2.40 in, Height: 2.00 in, Length: 10.80 in

Supplier: Genetex

Protein extract from Human Small intestine (normal) Pkg Size: 200 ug

Supplier: Genetex

Protein extract from Human Small Intestine: Jejunum (Diabetes) Pkg Size: 200 ug

Supplier: Genetex

Protein extract from Human Small intestine: Ileum (normal) Pkg Size: 200 ug

Supplier: Genetex

Protein extract from Human Small Intestine: Duodenum (normal) Pkg Size: 200 ug

Supplier: Genetex

Protein extract from Human Small intestine: Jejunum (Liver Cirrhosis) Pkg Size: 200 ug

Supplier: Genetex

Protein extract from Human Small Intestine: Duodenum (Liver Cirrhosis) Pkg Size: 200 ug

Supplier: GREAT LAKES GAGES, LLC

LED pocket flashlight, produces 200 lumens and provides projection distance of 250 meters. Small (26 x 118mm), portable and light weighted (73gr) The light is supplied with holster, wriststrap, 3xAAA alkaline batteries and giftbox

Supplier: SE International

Radiation Survey meter, Monitor 200, Handheld, Small end window, Detecting alpha, beta, gamma, and x-rays has a backlit digital display, a red count light, and beeper that sounds with each count detected Includes selectable alert levels, adjustable timer

Supplier: Remco Products

Vikan* Dish Brush with scraper, Color: Pink, Block Material: Polypropylene, Bristle Material: Polyester, Bristle Stiffness: Medium, perfectly for corners, small scraper at the tip to loosen stubborn debris, Width: 2.40 in, Height: 2.00 in, Length: 10.80 in

Supplier: Genetex

Protein extract from Human Small Intestine: Duodenum (Diabetes) Pkg Size: 200 ug

Supplier: Genetex

Protein extract from Human Small intestine (Liver Cirrhosis) Pkg Size: 200 ug

Supplier: IBI Scientific

Smoke Signature* Assay (Blood), Epigenetic test for quantifying cigarette smoking using a small amount of DNA from whole blood, Detects changes in the DNA methylation, Frst smoking detection/quantification assay, For digital PCR technologies, Size: 200 reactions