86 Results for: "galanin"

Supplier: Bachem Americas

The galanin antagonist M35, which binds with high specificity and affinity to galanin binding sites, has been administered to rats to test the functional consequences of the galanin receptor blockade in a spatial learning task. The results suggest that galanin antagonists might provide a new principle in the treatment of dementia and related disorders. M35 (but not M40 or C7) ameliorated cerulein-induced acute pancreatitis in mice.

Supplier: AFG BIOSCIENCE LLC

Bovine Galanin (GAL) ELISA Kit, AFG Bioscience

Supplier: Genetex

Mouse polyclonal antibody to Galanin

Supplier: AFG BIOSCIENCE LLC

Mouse Galanin Receptor Type 2(GALR2) ELISA Kit

Supplier: Prosci

Polyclonal antibody Galanin Receptor 3 Host: Goat Target Species: human immunogen: Galanin Receptor 3 antibody was raised against a 14 amino acid synthetic peptide near the C-Terminus of Galanin Receptor 3. Application: ELISA, WB

Supplier: Bachem Americas

The isolation and characterization of cDNAs encoding rat galanin and its precursor peptide reveal that rat galanin is synthesized initially as part of a 124-amino acid precursor that includes a signal peptide, galanin, and a 60-amino acid galanin mRNA-associated peptide. The neuropeptide galanin shows multiple inhibitory actions on neurotransmission and memory. In Alzheimer's disease, increased galanin-containing fibers hyperinnervate cholinergic neurons within the basal forebrain in association with a decline in cognition.

Supplier: Genetex

Rabbit Polyclonal to Human Galanin Receptor GalR2

Supplier: AFG BIOSCIENCE LLC

Rat GAL (Galanin) ELISA Kit

Supplier: Prosci

Galanin Receptor 3 Peptide

Supplier: AFG BIOSCIENCE LLC

Mouse Galanin Prepropeptide (GAL) ELISA Kit

Supplier: AFG BIOSCIENCE LLC

Human Galanin Neuropeptide (GALP) ELISA Kit

Supplier: AFG BIOSCIENCE LLC

Mouse Galanin Receptor Type 1(GALR1) ELISA Kit

Supplier: Genetex

Rabbit polyclonal antibody to galanin receptor 1 (galanin receptor 1)

Supplier: Genetex

Rabbit Polyclonal antibody to Galanin Receptor 2 (galanin receptor 2)

Supplier: Bachem Americas

The chimaeric peptide galantide is a high-affinity ligand for galanin receptors in membranes from rat hypothalamus, hippocampus, and spinal cord. There it reversibly blocks the neuronal actions of galanin in a dose-dependent manner. The peptide also reverses the galanin-mediated inhibition of insulin release from mouse pancreatic islets. Antagonists such as galantide are therefore of potential importance both as therapeutic agents and in studies on the physiological roles of galanin.

Supplier: Bachem Americas

Neuropeptide originally isolated from porcine upper small intestine.

Supplier: Bachem Americas

Galanin-like peptide (GALP), first isolated from the porcine hypothalamus and subsequently also identified in rats and humans, is a 60 amino acid neuropeptide that unlike galanin, has a non-amidated C-terminus. Its amino acid residues (9-21) are identical to the biologically active N-terminal (1-13) fragment of galanin. In contrast to galanin which is relatively non-selective, receptor binding studies revealed that GALP had a high affinity for the galanin receptor 2 (GALR2) and a lower affinity for the GALR1 receptor. Furthermore, it could be demonstrated that GALP stimulates food intake with a ten fold higher orexigenic activity than galanin and may also affect emotional state in the CNS.

Supplier: Bachem Americas

Human galanin, a 30-amino acid non-amidated peptide, has originally been isolated from colon and pituitary. Its sequence differs from that of rat and porcine galanins by 4 and 6 amino acids in the C-terminal moiety, respectively. Synthetic human galanin is equipotent to the rat peptide in the isolated rat fundus muscle strip bioassay. Both peptides also fully activate the rat galanin receptor, indicating the importance of the conserved N-terminal portion of galanin for receptor interaction. Galanin, which is widely distributed in the CNS, and GAL receptors (GALR) are overexpressed in limbic brain regions associated with cognition in Alzheimer disease. As galanin inhibits acetylcholine release, galanin antagonists have gained interest in AD research.

Supplier: AFG BIOSCIENCE LLC

Chicken Galanin (GAL) ELISA Kit

Supplier: Bachem Americas

This member of the galanin family has been isolated from porcine hypothalamus. It is a 60 amino acid peptide that, unlike galanin, has a non-amidated C-terminus. GALP amino acid residues (9-21) are identical to the biologically active N-terminal (1-13) portion of galanin. Receptor binding studies revealed that GALP had a high affinity for the galanin receptor 2 (GALR2; IC₅₀ = 0.24 nM) and a lower affinity for the GALR1 receptor (IC₅₀ = 4.3 nM). GALP is therefore an endogenous ligand that preferentially binds the GALR2 receptor, whereas galanin is relatively non-selective.

Supplier: Bachem Americas

Galanin-like peptide (GALP) is a 60 amino acid neuropeptide first isolated from the porcine hypothalamus and subsequently also identified in rats and humans. GALP exhibits a higher affinity (~18-fold) for the GALR2 receptor compared to the GALR1 receptor, whereas galanin is relatively non-selective. Investigations of the physiological role of GALP revealed that GALP induces food intake with a ten times higher orexigenic activity than galanin. Furthermore, GALP could affect the emotional state in the CNS. Therefore, GALP represents an orexigenic and anxiogenic peptide.

Supplier: AFG BIOSCIENCE LLC

Mouse Galanin-like Peptide(GALP) ELISA Kit

Supplier: Bachem Americas

Alarin, APAHRSSTFPKWVTKTERGRQPLRS, is derived from a splice variant of galanin-like peptide (GALP) RNA. It shows potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, as was also observed with other members of the galanin peptide family. Since alarin only shares five amino acids with GALP it is unlikely that the peptide can activate GALP-specific receptors. The neuropeptide has been reported to be expressed in ganglionic cells of human neuroblastic tumors and might therefore represent a potential tumor marker.

Supplier: ANTIBODIES.COM LLC

This Rat Galanin peptides ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Rat Galanin peptides in plasma, tissue homogenates and other biological fluids.

Supplier: ANTIBODIES.COM LLC

Human Galanin ELISA kit is a sandwich Enzyme-Linked Immunosorbent Assay (sELISA) designed for the in vitro quantitative determination of human Galanin in serum, plasma, tissue homogenates, and other biological fluids.

Supplier: AFG BIOSCIENCE LLC

Human Galanin (GAL) ELISA Kit, AFG Bioscience

Supplier: Genetex

Rabbit Polyclonal antibody to Galanin Receptor 2 (galanin receptor 2)

Supplier: AFG BIOSCIENCE LLC

Human Galanin-like peptide(GALP) ELISA Kit

Supplier: Genetex

Goat polyclonal antibody to Galanin Receptor 3

Supplier: Bachem Americas

The galanin receptor agonist galnon binds to the same brain-surface proteins, or receptors, that galanin does and prevents seizures. This drug mimicking a natural substance in the brain may represent a prototype for a new class of epilepsy drugs.