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2714 results for "Shenandoah Biotechnology"

2714 Results for: "Shenandoah Biotechnology"

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Rat Recombinant FGF-basic (from E. coli)

Rat Recombinant FGF-basic (from E. coli)

Supplier: Fujifilm Irvine Scientific

Basic fibroblast growth factor (FGF-basic), also known as FGF-2, is expressed by endothelial cells and is a mediator of angiogenesis. FGF-basic also has cardioprotective functions during heart injury. FGF-basic binds heparin in order to signal through fibroblast growth factor (FGF) receptor tyrosine kinases.

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Mouse Recombinant FGF-9 (from E. coli)

Mouse Recombinant FGF-9 (from E. coli)

Supplier: Fujifilm Irvine Scientific

Fibroblast growth factor 9 (FGF-9) is a mitogen and survival factor for nerve and mesenchymal cells. FGF-9 functions as an autocrine and paracrine factor to support the growth and survival of motor neurons and prostate tissue. FGF-9 expression in the gonad is also necessary for sex determination.

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Mouse Recombinant IL-5 (from E. coli)

Mouse Recombinant IL-5 (from E. coli)

Supplier: Fujifilm Irvine Scientific

Interleukin 5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. IL-5 acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. IL-5 expression is regulated by the GATA binding protein 3 (GATA3) transcription factor. Human and mouse IL-5 show cross-reactivity.

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Human Recombinant PDGF-BB (Animal free) (from E. coli)

Human Recombinant PDGF-BB (Animal free) (from E. coli)

Supplier: Fujifilm Irvine Scientific

Receptor activator of nuclear factor kappa-B Ligand (RANK Ligand) is a cell-bound marker related to the tumor necrosis factor (TNF) family of proteins. RANK Ligand plays a critical role in bone metabolism and osteoclast differentiation. T cell expression of RANK Ligand promotes dendritic cell maturation.

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Antifoam C Medical Emulsion, Biotech Reagent, J.T.Baker®

Antifoam C Medical Emulsion, Biotech Reagent, J.T.Baker®

Supplier: VWR International

Antifoam C Medical Emulsion, Biotech Reagent, J.T.Baker®

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N,N-Dimethylformamide ≥99.9% (by GC), Supelco®

Supplier: MilliporeSigma

Flammable.

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Rat Recombinant IL-6 (from E. coli)

Rat Recombinant IL-6 (from E. coli)

Supplier: Fujifilm Irvine Scientific

Interleukin 6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions, is capable of promoting fever, and signals through the cell-surface type I cytokine receptor complex containing the IL-6Ra and gp130 chains.

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Human Recombinant EBI3 (Animal free) (from E. coli)

Human Recombinant EBI3 (Animal free) (from E. coli)

Supplier: Fujifilm Irvine Scientific

Epstein-Barr virus induced gene-3 (EBI3) is a secreted glycoprotein belonging to the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). EBI3 expression is induced in B-lymphocytes in response to Epstein-Barr virus infection. EBI3 forms heterodimers with p28 to form interleukin 27 (IL-27), and with p35 to form interleukin 35 (IL-35). Both IL-27 and IL-35 have anti-inflammatory and regulatory activity.

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Human Recombinant IL-5 (from E. coli)

Human Recombinant IL-5 (from E. coli)

Supplier: Fujifilm Irvine Scientific

Interleukin 5 (IL-5) is a hematopoietic growth factor that is expressed in type 2 T helper (Th2) cells, mast cells, and eosinophils. It acts through the IL-5 receptor (IL-5R), stimulates B cell growth, and mediates eosinophil activation. Human and mouse IL-5 show cross-reactivity.

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Human Recombinant I-TAC (from E. coli)

Human Recombinant I-TAC (from E. coli)

Supplier: Fujifilm Irvine Scientific

Interferon-inducible T cell alpha chemoattractant (I-TAC), or CXCL11, is expressed at high levels in leukocytes, pancreas, and liver cells. I-TAC gene expression is induced by interferons alpha (IFN-α), beta (IFN-β), and gamma (IFN-ɣ). I-TAC is the dominant ligand known to bind the chemokine receptor CXCR3, thus acting as a stronge agonist. I-TAC functions as a chemoattractant for interleukin 2 (IL-2)-activated T cells.

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Human Recombinant CTGrade GMP rh IL-7 (from E. coli)

Supplier: Fujifilm Irvine Scientific

CTGrade GMP rh IL-7 is a recombinant human protein that is produced from E. coli and is designed to support basic, translational, and clinical research, as well as commercial applications.

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Human Recombinant Leptin (from E. coli)

Human Recombinant Leptin (from E. coli)

Supplier: Fujifilm Irvine Scientific

Leptin is a hormone that is produced by adipose tissue and plays critical roles in the physiologic regulation of body weight. Leptin acts through the leptin receptor (LEPR) to regulate adipose mass by inhibiting hunger and balancing energy usage. Leptin mutations cause severe hereditary obesity and hypogonadism in rodents and humans. Leptin also has thermogenic actions, regulates enzymes of fatty acid oxidation, and is involved in hematopoiesis, angiogenesis, wound healing, inflammation, and immune responses.

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Human Recombinant EBI3 (from E. coli)

Human Recombinant EBI3 (from E. coli)

Supplier: Fujifilm Irvine Scientific

Epstein-Barr virus induced gene-3 (EBI3) is a secreted glycoprotein belonging to the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). EBI3 expression is induced in B-lymphocytes in response to Epstein-Barr virus infection. EBI3 forms heterodimers with p28 to form interleukin 27 (IL-27), and with p35 to form interleukin 35 (IL-35). Both IL-27 and IL-35 have anti-inflammatory and regulatory activity.

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Mouse Recombinant FOLLISTATIN (from E. coli)

Mouse Recombinant FOLLISTATIN (from E. coli)

Supplier: Fujifilm Irvine Scientific

Resistin-like molecule-alpha (RELM-α) is a member of the RELM family of secreted proteins containing conserved C-terminus cysteines. The RELM family consists of Resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-γ (FIZZ4). RELM-α and Resistin are secreted by adipocytes, unlike RELM-β which is secreted by gastrointestinal epithelial cells, and RELM-γ which is expressed by peripheal blood granulocytes and bone marrow cells.

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Mouse Recombinant IL-6 (from E. coli)

Mouse Recombinant IL-6 (from E. coli)

Supplier: Fujifilm Irvine Scientific

Interleukin 6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions, is capable of promoting fever, and signals through the cell-surface type I cytokine receptor complex containing the IL-6Ra and gp130 chains. Human IL-6 is active on mouse and rat cells.

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Human Recombinant rh GM-CSF (GMP) (from E. coli)

Supplier: Fujifilm Irvine Scientific

CTGrade GMP rh GM-CSF is a recombinant human protein that is produced from E. coli and is designed to support preclinical and clinical research, as well as commercial applications.

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Mouse Recombinant SCF (from E. coli)

Mouse Recombinant SCF (from E. coli)

Supplier: Fujifilm Irvine Scientific

Stem cell factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. While human SCF shows no activity on murine cells, murine and rat SCF are active on human cells.

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Human Recombinant RANK LIGAND (from E. coli)

Human Recombinant RANK LIGAND (from E. coli)

Supplier: Fujifilm Irvine Scientific

Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling. IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.

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Human Recombinant CTGrade GMP rh IL-3 (from E. coli)

Supplier: Fujifilm Irvine Scientific

CTGrade GMP rh IL-3 is a recombinant human protein that is produced from E. coli and is designed to support basic, translational, and clinical research, as well as commercial applications.

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Human Recombinant SDF-1 A/CXCL12 (from E. coli)

Human Recombinant SDF-1 A/CXCL12 (from E. coli)

Supplier: Fujifilm Irvine Scientific

Interleukin 31 (IL-31) is an immunoregulatory cytokine that is expressed by activated type 2 T helper (Th2) cells. IL-31 signals through a heterodimer receptor consisting of the IL-31 Receptor A (IL-31RA) and the oncostatin M receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes. IL-31 promotes allergic reactions and inflammatory skin diseases.

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Human Recombinant MIP-3 B  (from E. coli)

Human Recombinant MIP-3 B (from E. coli)

Supplier: Fujifilm Irvine Scientific

Macrophage inflammatory protein-3 beta (MIP-3 β), also called CCL19, is a chemokine that is expressed in the thymus, lymph nodes, and activated bone marrow stromal cells. MIP-3 β signals through the G protein-coupled receptor CCR7 to regulate normal lymphocyte recirculation. MIP-3 β also functions during T cell trafficking to the thymus, and in T cell and B cell homing to the lymph nodes and secondary lymphoid organs. Human MIP-3 β shows activity on mouse cells.

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Human Recombinant IL-21 (Animal free) (from E. coli)

Human Recombinant IL-21 (Animal free) (from E. coli)

Supplier: Fujifilm Irvine Scientific

Interleukin 6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions, is capable of promoting fever, and signals through the cell-surface type I cytokine receptor complex containing the IL-6Ra and gp130 chains. Human IL-6 is active on mouse and rat cells.

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Mouse Recombinant IL-17AF  (from E. coli)

Mouse Recombinant IL-17AF (from E. coli)

Supplier: Fujifilm Irvine Scientific

Interleukin 11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Rα receptor to activate JAK downstream signaling.

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Mouse Recombinant IL-11 (from E. coli)

Mouse Recombinant IL-11 (from E. coli)

Supplier: Fujifilm Irvine Scientific

Interleukin 11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Rα receptor to activate JAK downstream signaling.

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Rat Recombinant FGF-basic (Animal free) (from E. coli)

Rat Recombinant FGF-basic (Animal free) (from E. coli)

Supplier: Fujifilm Irvine Scientific

Basic fibroblast growth factor (FGF-basic), also known as FGF-2, is expressed by endothelial cells and is a mediator of angiogenesis. FGF-basic also has cardioprotective functions during heart injury. FGF-basic binds heparin in order to signal through fibroblast growth factor (FGF) receptor tyrosine kinases. 

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Human Recombinant PDGF-AA (from E. coli)

Supplier: Fujifilm Irvine Scientific

CTGrade GMP rh PDGF-AA is a recombinant human protein that is produced from E. coli and is designed to support preclinical and clinical research, as well as commercial applications. 50 µg, 100 µg, and 1 mg sizes are available.

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Mouse Recombinant IFN-G (from E. coli)

Mouse Recombinant IFN-G (from E. coli)

Supplier: Fujifilm Irvine Scientific

Interferon gamma (IFN-γ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFN-γ is produced by T cells and natural killer cells following antigen-specific activation. IFN-γ binds IFN-γ receptors (IFN-γ R1 and IFN-γ R2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFN-γ-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Mouse IFN-γ is not cross-reactive with human IFN-γ.

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Ward's® Basic Electrophoresis Bundles

Ward's® Basic Electrophoresis Bundles

Supplier: Avantor

These bundles are everything you need to perform agarose gel electrophoresis.

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Human Recombinant SDF-1 A/CXCL12 (from E. coli)

Human Recombinant SDF-1 A/CXCL12 (from E. coli)

Supplier: Fujifilm Irvine Scientific

Stromal cell-derived factor-1 alpha (SDF-1 α), also called CXCL12a, is one of two SDF-1 splice variants made by a wide variety of cells upon stimulation by inflammatory cytokines such as TNF, IL-1, and LPS. SDF-1α signals through the G protein-coupled receptor CXCR4 to recruit activated leukocytes. Human and mouse SDF-1 α share 99% sequence identity.

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Mouse Recombinant TPO (Animal free) (from E. coli)

Mouse Recombinant TPO (Animal free) (from E. coli)

Supplier: Fujifilm Irvine Scientific

Exodus-2, also known as CCL21 and 6Ckine, is a chemokine that is strongly produced in the human lymph nodes and spleen. Exodus-2 signals through the chemokine receptor CCR7 to regulate thymocyte and activated T cell migration. Exodus-2 also mediates the homing of lymphocytes to the lymphatic system. Human and mouse Exodus-2 proteins share greater than 85% amino acid sequence identity.

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