5925 Results for: "SMALP b220"

Supplier: Tonbo Biosciences

The UCHL1 antibody reacts with the human CD45 isoform known as CD45RO, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA and CD45RB. The UCHL1 antibody is widely used as a marker for human CD45RO expression on thymocytes, activated memory T cells, monocytes, macrophages and granulocytes. The antibody is reported to be cross-reactive for Chimpanzee CD45RO.

Supplier: Biolegend

Purified anti-mouse/human CD45R/B220 [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC, CyTOF®, IP, IHC; Size: 500 μg

Supplier: Biolegend

Alexa Fluor® 488 anti-mouse/human CD45R/B220 [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC, IHC, IF; Size: 25 μg

Supplier: Biolegend

Brilliant Violet 785™ anti-mouse/human CD45R/B220 [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC; Size: 50 μg

Supplier: Biolegend

Brilliant Violet 650™ anti-mouse/human CD45R/B220 [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC; Size: 125 μl

Supplier: Tonbo Biosciences

The 2D1 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, and CD45RO.

Supplier: Tonbo Biosciences

The HI30 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others.

Supplier: Biolegend

PerCP anti-mouse/human CD45R/B220 [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC; Size: 100 μg

Supplier: Biolegend

FITC anti-mouse/human CD45R/B220 [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC; Size: 500 μg

Supplier: Biolegend

APC/Cy7 anti-mouse/human CD45R/B220 [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC; Size: 100 μg

Supplier: Biolegend

Alexa Fluor® 700 anti-mouse/human CD45R/B220 [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC; Size: 100 μg

Supplier: Tonbo Biosciences

The Mouse Dendritic Cell backbone panel is a six-color combination of anti-mouse antibodies. This panel can serve as a backbone for identifying major dendritic cell (DC) subsets. Hosts: Rat, Armenian Hamster

Supplier: Tonbo Biosciences

The 30-F11 antibody reacts with mouse CD45, which is one of the most abundant hematopoietic markers and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB and CD45RO.

Supplier: Biolegend

Brilliant Violet 711™ anti-mouse/human CD45R/B220 [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC; Size: 50 μg

Supplier: Bioss

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Supplier: Tonbo Biosciences

The HI100 antibody reacts with the human CD45 isoform known as CD45RA, a protein tyrosine phosphatase of 220 kDa. CD45 is one of the most abundant hematopoietic markers, and is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RB, CD45RO and others. The HI100 antibody is widely used as a marker for human CD45RA expression on naive and activated T cells, B cells, and monocytes.

Supplier: Bioss

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Supplier: Bioss

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Supplier: Bioss

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Supplier: Biolegend

PE/Dazzle™ 594 anti-mouse/human CD45R/B220 [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC; Size: 100 μg

Supplier: Bioss

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Supplier: Bioss

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Supplier: Biolegend

Alexa Fluor® 594 anti-mouse/human CD45R/B220 [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC, IHC, IF; Size: 100 μg

Supplier: Bioss

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Supplier: Biolegend

Purified anti-mouse/human CD45R/B220 (MaxPar® Ready) [RA3-6B2]; Isotype: Rat IgG2a, κ; Reactivity: Mouse, Human, Cross-Reactivity: Cat (Feline); Apps: FC, CyTOF®; Size: 100 μg

Supplier: Bioss

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Supplier: Bioss

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Supplier: Tonbo Biosciences

The FITC Mouse Lineage Cocktail contains a combination of pre-diluted antibodies that identify lineage committed cells by flow cytometry and facilitate their exclusion from hematopoietic progenitor cells in mouse bone marrow. The antibodies in the cocktail react with cells from major hematopoietic lineages including T, B and NK cells, monocytes/macrophages, granulocytes and erythrocytes. The Lineage Cocktail contains the following FITC conjugated antibodies: anti-mouse CD3 (17A2), anti-mouse CD11b (M1/70), anti-mouse CD45/B220 (RA3-6B2), anti-mouse Ly-6G (Gr-1) (RB6-8C5) and anti-mouse TER-119 (TER-119). An Isotype Control Cocktail consisting of FITC conjugated isotype-matched control antibodies (Rat IgG2a, kappa; Rat IgG2b, kappa) is also provided in a separate vial.

Supplier: Bioss

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Supplier: Biotium

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemias of B-cell origin.