9693 Results for: "Proteintech"

Supplier: Proteintech

The GAGE7 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GAGE7. This antibody recognizes human antigen. The GAGE7 antibody has been validated for the following applications: ELISA, IHC, WB analysis.

Supplier: Proteintech

The CLP1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CLP1. This antibody recognizes human, mouse antigen. The CLP1 antibody has been validated for the following applications: ELISA, WB analysis.

Supplier: Proteintech

The DKC1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human DKC1. This antibody recognizes human antigen. The DKC1 antibody has been validated for the following applications: ELISA, WB analysis.

Supplier: Proteintech

The ADAM8 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ADAM8. This antibody recognizes human, mouse antigen. The ADAM8 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Supplier: Proteintech

The UPK3B antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human UPK3B. This antibody recognizes human, mouse antigen. The UPK3B antibody has been validated for the following applications: ELISA, IHC, IP analysis.

Supplier: Proteintech

The TSN antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human TSN. This antibody recognizes human, mouse antigen. The TSN antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.

Supplier: Proteintech

The ST8SIA1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human ST8SIA1. This antibody recognizes human antigen. The ST8SIA1 antibody has been validated for the following applications: ELISA, WB analysis.

Supplier: Proteintech

Numbl (also known as numblike or Nbl), as a conserved homolog of Drosophila Numb, is specfically expressed in the brain. Numbl is a cytoplasm protein and has redundant functions in embryonic neurogenesis. It plays an important role in ependymal wall integrity and subventricular zone neuroblast survival. However, its expression and function in the central nervous system lesion are still unclear.

Supplier: Proteintech

The SOX17 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SOX17. This antibody recognizes human, mouse, rat antigen. The SOX17 antibody has been validated for the following applications: ELISA, WB analysis.

Supplier: Proteintech

The AKAP8L antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AKAP8L. This antibody recognizes human antigen. The AKAP8L antibody has been validated for the following applications: ELISA, WB, IF analysis.

Supplier: Proteintech

The DTX4 Antibody from Proteintech is a rabbit polyclonal Antibody to a fusion protein of human DTX4. This Antibody recognizes human, mouse Antigen. The DTX4 Antibody has been validated for the following applications: ELISA, WB, IF analysis.

Supplier: Proteintech

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin (ZYX) is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles.

Supplier: Proteintech

Anti-RABAC1 Antibody, Host Species: Rabbit, Cross Reactivity: Human,Mouse,Rat, Immunogen: Recombinant Protein, 1-185 amino acid, Format:Antigen affinity purification, Application: ELISA, IHC, WB, Recommended Storage: - 20 C or lower

Supplier: Proteintech

Interferon-gamam (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit which attaches to IFN-γ with a significantly lower affinity. Two subunits bind one IFN-γ dimer. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection.

Supplier: Proteintech

Pantothenate kinase 2 (PANK2) is an essential regulatory enzyme in coenzyme A biosynthesis. PANK2 mutations cause pantothenate kinase-associated neurodegeneration (PKAN), which leads to pigmentary retinopathy, progressive dystonia and other abnormalities. PanK2 protein is localized to mitochondria of neurons in human brain, distinguishing it from other pantothenate kinases that do not possess mitochondrial-targeting sequences. It has 4 isoforms produced by alternative splicing and alternative initiation.

Supplier: Proteintech

KAT5 belongs to the MYST protein family that contains atypical zinc finger and histone acetyltransferase domains. Also, KAT5 contains a chromodomain. KAT5 is a catalytic subunit of the NuA4 histone acetyltransferase complex. The NuA4 HAT complex plays a role in transcriptional activation of select genes mainly by acetylation of nucleosomal histone H4 and H2A, which influence nucleosome-DNA interaction and promotes interaction of the modified histones with other proteins that could regulate transcription positively. This complex also involves in the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, DNA repair and apoptosis.

Supplier: Proteintech

ARPP-19, a 19-kDa cAMP-regulated phosphoprotein, plays a role in regulating mitosis. Initiation and maintenance of mitosis require the activation of protein kinase cyclin B–Cdc2 and the inhibition of protein phosphatase 2A (PP2A). When phosphorylated by protein kinase Greatwall (Gwl), ARPP-19 associate with and inhibit PP2A, thus promoting mitotic entry. ARPP-19 may be an important link between nerve growth factor (NGF) signaling and post-transcriptional control of neuronal gene expression such as GAP-43.

Supplier: Proteintech

Anti-NUDT2 Antibody, Host Species: Rabbit, Cross Reactivity: Human,Mouse,Rat, Immunogen: Recombinant Protein, 1-149 amino acid, Format:Antigen affinity purification, Application: ELISA, WB, IHC, Recommended Storage: - 20 C or lower

Supplier: Proteintech

Anti-YY1AP1 Antibody, Host Species: Rabbit, Cross Reactivity: Human, Immunogen: Recombinant Protein, 1-400 amino acid, Format:Antigen affinity purification, Application: ELISA, IF, WB, Recommended Storage: - 20 C or lower

Supplier: Proteintech

IFT57, also named as DERP8, ESRRBL1, HIPPI and MHS4R2, belongs to the IFT57 family. It is required for the formation of cilia. IFT57 plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. It is a component of IFT complex B which composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20. In contrast to BBS proteins, IFT57 and IFT88 is found in almost every cilium.

Supplier: Proteintech

Anti-P120-CATENIN Antibody, Host Species: Rabbit, Cross Reactivity: Human,Mouse,Rat, Immunogen: Recombinant Protein, C-term-286 amino acid, Format:Antigen affinity purification, Application: ELISA, WB, IF, Recommended Storage: - 20 C or lower

Supplier: Proteintech

VCP(Valosin-containing protein) belongs to the AAA ATPase family.VCP was first identified as a result of attempts to clone a putative peptide hormone called valosin. It was found that the cloned cDNA encoded a ubiquitously expressed 90 kDa cytosolic protein, termed VCP, which showed none of the characteristics of a peptide hormone precursor.Defects in VCP are the cause of inclusion body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD) and amyotrophic lateral sclerosis type 14 with or without frontotemporal dementia (ALS14).

Supplier: Proteintech

AKR7A2(Aflatoxin B1 aldehyde reductase member 2) is also named as AFAR, AFAR1, AKR7 and belongs to the aldo/keto reductase family. AKR7A2 enzyme is catalytically active toward aldehydes arising from lipid peroxidation, suggesting a potential role against the consequences of oxidative stress, and representing an important detoxication route in mammalian cells.

Supplier: Proteintech

AP3B1 is the 140-kDa β3A subunit of the adaptor-related protein complex-3 (AP-3), a ubiquitous heterotetrameric complex that is localized to the trans-Golgi network and endosomes and is involved in protein trafficking to lysosomes or specialized endosomal-lysosomal organelles . This complex is composed of two lager subunits (δ and β3A or β3B), a medium subunit (μ3A or μ3B), and a small subunit (σ3A or σ3B). The absence of the β3A subunit (AP3B1) results in the loss of stability of AP3 and leads to degradation of μ3A, to which β3A is directly bound, while the other subunits are variably affected . AP3B1 contains three main domains: the N-terminal head domain, the hinge, and the C-terminal ear domain. It has been reported as a target of IP(7)-mediated pyrophosphorylation . Defects in AP3B1 are the cause of Hermansky-Pudlak syndrome type 2 (HPS2) .

Supplier: Proteintech

The IL33 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human IL33. This antibody recognizes human antigen. The IL33 antibody has been validated for the following applications: ELISA, WB analysis.

Supplier: Proteintech

Anti-IL5RA Antibody, Host Species: Rabbit, Cross Reactivity: Human,Mouse,Rat, Immunogen: Recombinant Protein, 50-335 amino acid, Format:Antigen affinity purification, Application: ELISA, WB, IHC, IF, Recommended Storage: - 20 C or lower

Supplier: Proteintech

The 2-prime,5-prime oligoadenylate synthetases (OASs), such as OAS1, are interferon-induced proteins characterized by their capacity to catalyze the synthesis of 2-prime,5-prime oligomers of adenosine (2-5As). OAS1 (type I enzymes) have molecular weights of 42, 44, 46, and 48 kDa, form tetramers, and contain a single consensus sequence. OAS1 is a strong candidate for determining susceptibility or resistance to viral infections.

Supplier: Proteintech

CSDE1 (Cold shock domain-containing protein E1), also known as UNR (upstream of N-ras), is an RNA-binding protein involved in the regulation of messenger RNA stability and internal initiation of translation. It is required for internal initiation of translation of human rhinovirus RNA. UNR may be involved in translationally coupled mRNA turnover. Reduced expression of UNR impairs proliferation and differentiation of erythroid blasts. Recent study found that UNR acts as a positive or negative regulator of cell death, depending on the cell type, suggesteing manipulation of UNR level may constitute a specific approach to sensitize cancer cells to anticancer treatments.

Supplier: Proteintech

Anti-RANGAP1 Antibody, Host Species: Rabbit, Cross Reactivity: Human,Mouse,Rat, Immunogen: Recombinant Protein, C-term-350 amino acid, Format:Antigen affinity purification, Application: ELISA, WB, IHC, IF, Recommended Storage: - 20 C or lower

Supplier: Proteintech

Polypyrimidine tract-binding protein (PTBP1), also known as heterogeneous nuclear ribonucleoprotein type I (hnRNP I), is a nuclear protein that binds pre-mRNAs in specific regions of the hnRNA-protein complexes sensitive to micrococcal nuclease. It involves in pre-mRNA splicing and the regulation of alternative splicing events. PTBP1 promotes RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA, and promotes the binding of U2 snRNP to pre-mRNA. Besides, it can cooperate with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA, and represses the splicing of MAPT/Tau exon 10