1030 Results for: "PPDT2FBT (ph7.2)"

Supplier: BIOGEMS INTERNATIONAL INC.

The H1.2F3 monoclonal antibody specifically reacts with human CD69, the 27-33 kDA type II transmembrane protein also known as the very early activation antigen (VEA) or the activation inducer molecule (AIM). It is expressed as a disulfide-linked dimer on B cells, T cells, NK cells, platelets, eosinophils, and neutrophils. It increases in expression upon cell activation and seems to serve a role as a signaling receptor.

Supplier: BIOGEMS INTERNATIONAL INC.

The 2A3 antibody was obtained by hybridization of MouseNS-1 myeloma cells with spleen cells harvested from BALB/c mice immunized with phytohemagglutinin-activated human T cells. The 2A3 antibody is a CD25 clone and used as an Isotype Control for rat IgG2a antibodies. BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

Supplier: BIOGEMS INTERNATIONAL INC.

The HI100 monoclonal antibody specifically reacts with human CD45RA, the 220 kDa isoform of the human leukocyte common antigen (LCA) found on 40-50% of the peripheral CD4+ T lymphocytes, half of the peripheral CD8+ T lymphocytes and some of the monocytes and B lymphocytes. The CD45RA antigen is expressed by naïve and activated T lymphocytes. The HI100 monoclonal antibody is used as a phenotypic marker to discriminate T lymphocytes subsets.

Supplier: BIOGEMS INTERNATIONAL INC.

The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the α subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127.

Supplier: BIOGEMS INTERNATIONAL INC.

The SN3 monoclonal antibody specifically reacts with human CD24, a 35-45 kDA molecule also known as the Heat Stable Antigen (HAS), Ly-52, Nectadrin. It can be used as a marker for distinguishing between lymphocyte developmental stages as its expression varies on T and B cells during differentiation. CD24 is also expressed on monocytes, dendritic cells, hematopoietic stem cells, epidermal Lagershans cells, and neurons.

Supplier: BIOGEMS INTERNATIONAL INC.

The G4.18 monoclonal antibody specifically reacts with rat CD3, a T cell lineage marker and associated with the T cell receptor (TCR). CD3 is involved in antigen recognition, cell activation, and signal transduction and is found on subsets of NK-T, peripheral T, dendritic epidermal T, and thymocyte cells. Immobilized G4.18 antibody activates T cells in vitro and in vivo treatments of the G4.18 antibody prevents cardiac and skin allograft rejection.

Supplier: BIOGEMS INTERNATIONAL INC.

The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.

Supplier: BIOGEMS INTERNATIONAL INC.

The Hit3a monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.The HIT3a antibody cross-links with the TCR complex, initiating the cellular activation and proliferation, but it cannot be used for intracellular CD3 staining, as it is able to stain only the surface CD3 complex.

Supplier: BIOGEMS INTERNATIONAL INC.

The 61D3 monoclonal antibody specifically reacts with CD14, a cell surface anchored glycoprotein that is primarily expressed on monocytes, inerfollicular macrophages, and a subset of dendritic cells. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappaB.

Supplier: BIOGEMS INTERNATIONAL INC.

The HI149 monoclonal antibody specifically reacts with human CD1a, a 49kDA type I membrane glycoprotein. It is expressed on dendritic cells, Langerhans cells, and cortical thymocytes. CD1a plays a role in antigen presentation and ,like MHC Class I, it non-covalently associates with Beta2-microglobulin.

Supplier: BIOGEMS INTERNATIONAL INC.

The LN3 monoclonal antibody specifically reacts with the human leukocyte antigen-DR (HLA-DR), a MHC class II heterodimeric surface glycoprotein. HLA-DR is expressed on the antigen presenting surfaces of monocytes, macrophages, dendritic cells, activated T cells, and B cells. It is integral to peptide presentation to CD4+ T cells.

Supplier: BIOGEMS INTERNATIONAL INC.

The 10.1 monoclonal antibody specifically reacts with human CD64, a 75kDA type I transmembrane glycoprotein that is the high affinity receptor for IgG. CD64 is expressed on macrophages and dendritic cells and is involved in antibody-dependent cellular toxicity, cytokine release phagocytosis, and endocytosis. The 10.1 antibody is reported to recognize the EC3 epitope of CD64.

Supplier: BIOGEMS INTERNATIONAL INC.

The 4H1 monoclonal antibody specifically bind to human CD116, a 70-85 kD alpha chain of the GM-CSF receptor. It forms the high affinity GM-CSF receptor with CD131 as the beta chain. CD116 is expressed on macrophages, monocytes, eosinophils, dendritic cells, fibroblasts, neutrophils, and some tumor cells.

Supplier: BIOGEMS INTERNATIONAL INC.

The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells. CD27 is upregulated by T lymphocytes stimulation, and binds to CD70, enhancing the interaction between T and B lymphocytes. CD27 is a marker of memory B cells.

Supplier: BIOGEMS INTERNATIONAL INC.

The O323 monoclonal antibody specifically binds to the human CD27, which is a lymphocyte-specific member of the TNF/NGF-R family, expressed on a subset of human thymocytes and the majority of the mature T cells. CD27 is upregulated by T lymphocytes stimulation, and binds to CD70, enhancing the interaction between T and B lymphocytes. CD27 is a marker of memory B cells.

Supplier: BIOGEMS INTERNATIONAL INC.

The TBO1 monoclonal antibody specifically binds to human CD57, a 110 kDA glycoprotein expressed on a subset of natural killer lymphocytes, cells, neural cells and striated muscle. It is reported that the molecule is involved in cell-matrix interactions and is upregulated in some disease states.

Supplier: BIOGEMS INTERNATIONAL INC.

The WM-15 monoclonal antibody specifically reacts with human CD13, 150-170 type II transmembrane ectoenzyme also named aminopeptidase N and gp150. It is expressed by granulocytes and monocytes, epithelial cells, and endothelial cells. CD13 plays a role in the terminal degradation of peptides, antigen processing, and chemokine cleavage, and cellular adhesion.

Supplier: BIOGEMS INTERNATIONAL INC.

The AD2 monoclonal antibody specifically reacts with human CD73 (ecto-5’-nucleotidase), a 70 kDA glycosyl phosphatidylinositol (GPI)-anchored glycoprotein. CD73 catalyzes the dephosphorylation of adenosine monophosphate (AMP) to adenosine and is expressed on subsets of B, T, dendritic, endothelial, and mesenchymal stem cells. It is also involved in the adhesion of lymphocytes to endothelium and T cell activation.

Supplier: BIOGEMS INTERNATIONAL INC.

The HI100 monoclonal antibody specifically reacts with human CD45RA, the 220 kDa isoform of the human leukocyte common antigen (LCA) found on 40-50% of the peripheral CD4+ T lymphocytes, half of the peripheral CD8+ T lymphocytes and some of the monocytes and B lymphocytes. The CD45RA antigen is expressed by naïve and activated T lymphocytes. The HI100 monoclonal antibody is used as a phenotypic marker to discriminate T lymphocytes subsets.

Supplier: BIOGEMS INTERNATIONAL INC.

The 2H7 monoclonal antibody specifically reacts with human CD20, a 33-37kDA B-lymphocyte surface molecule. CD20 is an unglycosylated four-transmembrane phosphoprotein expressed by B cells in all stage of development, except the final plasma cells. It has been reported that the molecule is involved in B cell activation and has also been observed on a subset of circulating T lymphocytes.

Supplier: BIOGEMS INTERNATIONAL INC.

The HTA125 monoclonal antibody specifically reacts with human CD284, a 110kDA type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4). CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.

Supplier: BIOGEMS INTERNATIONAL INC.

The 1B1 monoclonal antibody specifically reacts with mouse CD1d, a 48kDA type I membrane glycoprotein with a structural homology to MHC class I molecules. CD1d is expressed by mouse leukocytes, epithelial cells, thymocytes, and dendritic cells and is the only molecules in the CD1 family to have been found in the mouse. The 1B1 antibody detects CD1d in association with the Beta2m molecule.

Supplier: BIOGEMS INTERNATIONAL INC.

The TS2/16 moncolonal antibody specifically reacts with human CD29 (Integrin beta1), a 130 kDA type I glycoprotein expressed on hematopoietic and non-hematopoietic cells. It forms the VLA-(1-6) molecules with integrin alpha-(1-6) and is involved in the adhesion between cell-cell and cell-matrix. The TS2/16 antibody has been found to activate beta 1 integrins.

Supplier: BIOGEMS INTERNATIONAL INC.

The HIT2 monoclonal antibody specifically bind to human CD38, a 45kda type II transmembrane glycoprotein. CD38 is expressed on activated T cells, plasma cells, monocytes, macrophages, dendritic cells, and thymocytes. CD38 displays cyclase and hydrolase enzymatic activity and is involved in lymphocyte adhesion, activation, and cell signaling. Its ligand is CD31.

Supplier: BIOGEMS INTERNATIONAL INC.

The HMJ1-29 monoclonal antibody reacts with mouse and rat CD339 (Jagged 1), a type 1 transmembrane Notch receptor ligand. It is expressed by macrophages and certain stromal, epithelial, dendritic, and thymic lymphoid cells. It has been reported to be play a role in Treg induction, Th2 polarization, neurogenesis, and cardiovascular development.

Supplier: BIOGEMS INTERNATIONAL INC.

The WM53 monoclonal antibody specifically reacts with human CD33, a 67 kDA transmembrane glycoprotein also known as GP67 and P67. CD33 is expressed on monocytes, granulocytes, dendritic cells, mast cells, and myeloid progenitors to the exclusion of hematopoietic stem cells, lymphocytes, and platelets. It functions to assist sialic acid-dependent cell adhesion.

Supplier: BIOGEMS INTERNATIONAL INC.

The 2B11 monoclonal antibody specifically reacts with mouse CD184 (CXCR4or Fusin), a seven-transmembrane G-protein-coupled receptor. It is expressed by astrocytes, B cells, T cells, monocytes, neutrophils, neurons, and hematopoietic cell types. CD184 is a coreceptor for X4 HIV-1.The monoclonal 2B11 antibody recognizes the amino terminus of CD184 and has functional activity.

Supplier: BIOGEMS INTERNATIONAL INC.

The MIH4 monoclonal antibody specifically reacts with human Programmed death-1 (PD-1 or CD279), a 50-55 kDA glycoprotein. It is expressed on mainly on activated B, T, and myeloid cells. Within the cytoplasmic region, PD-1 contains an Immunoreceptor tyrosine-based inhibitory motif (ITIM) and seems to regulate peripheral tolerance. The lack or mutation of CD279 is linked to autoimmune disorders.

Supplier: BIOGEMS INTERNATIONAL INC.

The 2H7 monoclonal antibody specifically reacts with human CD20, a 33-37kDA B-lymphocyte surface molecule. CD20 is an unglycosylated four-transmembrane phosphoprotein expressed by B cells in all stage of development, except the final plasma cells. It has been reported that the molecule is involved in B cell activation and has also been observed on a subset of circulating T lymphocytes.

Supplier: BIOGEMS INTERNATIONAL INC.

The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1. It is expressed on activated T cells and a group of thymocytes and is involved in the proliferation, activation, and cytokine production of T cells. When plate-bound, the ISA-3 antibody induces the production of IL-4,5,10 in T cells.