59 Results for: "PBDB-T-2F (pde1b)"

Supplier: Thermo Scientific Chemicals

PBDB-T-2F (PCE14), Poly[[4,8-bis[5-(2-ethylhexyl)-4-fluoro-2-thienyl]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl]-2,5-thiophenediyl[5,7-bis(2-ethylhexyl)-4,8-dioxo-4H,8H-benzo[1,2-c:4,5-c']dithiophene-1,3-diyl]-2,5-thiophenediyl], Formula: (C68H76F2O2S8)n, Synonyms: PCE135, Storage: Ambient, Size: 100mg

Supplier: Thermo Scientific Chemicals

PBDB-T-2Cl, Poly[[4, 8-bis[4-chloro-5-(2-ethylhexyl)-2-thienyl]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl]-2,5-thiophenediyl[5,7-bis(2-ethylhexyl)-4,8-dioxo-4H,8H-benzo[1,2-c:4,5-c]dithiophene-1,3-diyl]-2,5-thiophenediyl], Synonyms: PCE 139, Formula: (C68H76Cl2O2S8)n, Storage: Ambient, Size: 100mg

Supplier: Thermo Scientific Chemicals

PBDB-T (PCE12), Poly[(2,6-(4,8-bis(5-(2-ethylhexyl)thiophen-2-yl)-benzo[1,2-b:4,5-b]dithiophene))-alt-(5,5-(1,3-di-2-thienyl-5,7-bis(2-ethylhexyl)benzo[1,2-c:4,5-c]dithiophene-4,8-dione)], Formula: (C68H78O2S8)n, Storage and Sensitivity: Ambient temperatures, Size: 250mg

Supplier: Genetex

Mouse Monoclonal Antibody [5C4A3] to PDE1B

Supplier: Genetex

Mouse Monoclonal Antibody [10B10B12] to PDE1B

Supplier: VWR International

Organic liquid thermometer features a U-shaped tube mounted on a plastic casing with metal floats at the top of each column.

Supplier: Abgent

Polyclonal Antibody, Isotype: Rabbit Ig, Species Reactivity: Human, Gene ID: 5153, Target/Specificity: generated from rabbits immunized with a KLH conjugated synthetic peptide between 467-495 amino acids from the C-terminal region of human PDE1B

Supplier: Prosci

Anti-PDE1B Rabbit Polyclonal Antibody

Supplier: Genetex

Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-11) based on their kinetic properties and inhibition to various pharmacological agents. Three different PDE1 genes have been identified (PDE1A, B, and C). PDE1A and PDE1B have higher affinity for cGMP than for cAMP, whereas PDE1C has high affinity for both cAMP and cGMP. The PDE1A gene family includes various proteins that differ from each other at amino and carboxy termini of the protein. There are three novel PDE1A variants so far identified (PDE1A1; PDE1A3 and PD1A5), PDE1A5 encodes a 519 residue protein , which is different from PDE1A1 by insertion of 14 amino acid residues at the carboxy terminal and is also different from PDE1A3 by a divergent at N-terminus. The tissue distribution of PDE1A is different from other PDE1 gene family members. In testis PDE1A is highly expressed but in different stages of developing germ cells.

Supplier: Bioss

HOXB4 is a homeodomain-containing transcription factor with diverse roles in embryonic development and the regulation of adult stem cells. It promotes proliferation of hematopoietic stem cells and can both activate and repress apoptosis.

Supplier: HexArmor

Safety eyewear should never be treated as one size fits all. Simply wearing any generic pair of safety eyewear isn’t enough to protect the eyes.100% UV protection, metal-free

Supplier: Bioss

The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in this gene are a cause of Charcot-Marie-Tooth disease type 2F (CMT2F) and distal hereditary motor neuropathy (dHMN). [provided by RefSeq, Oct 2008].

Supplier: Genetex

Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodiesterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-11) based on their kinetic properties and inhibition to various pharmacological agents. Three different PDE1 genes have been identified (PDE1A, PDE1B, PDE1C). The enzymes of the PDE1A and PDE1B have higher affinity for cGMP than for cAMP, where as, PDE1C has high affinity for both cAMP and cGMP. Calcium-Calmodulin stimulates the activity of each of these enzymes several-fold. The PDE1C gene has been cloned from human, mouse and rat. The PDE1C gene codes a family of proteins (variants) that differ from each other at amino and carboxy termini of the protein. The tissue distribution of PDE1C is different from other PDE1 gene family members. A 5 splice variant of PDE1C2 is found in rat olfactory epithelium and is believed to be involved in olfactory signal transduction. Other PDE1C variants (PDE1C1 and PDE1C2) are found in human heart. The PDE1C enzymes bind both cGMP and cAMP with different affinities.

Supplier: Bioss

HOXB4 is a homeodomain-containing transcription factor with diverse roles in embryonic development and the regulation of adult stem cells. It promotes proliferation of hematopoietic stem cells and can both activate and repress apoptosis.

Supplier: Thermco

These high precision liquid-in-glass mercury thermometers are hand blown, which bear graduations, numbers and letters etched into the glass and filled with and inert gas above the mercury column

Supplier: Thermco

These high precision liquid-in-glass mercury thermometers are hand blown, which bear graduations, numbers and letters etched into the glass and filled with and inert gas above the mercury column

Supplier: HexArmor

Safety eyewear should never be treated as one size fits all. Simply wearing any generic pair of safety eyewear isn’t enough to protect the eyes.

Supplier: Bioss

HOXB4 is a homeodomain-containing transcription factor with diverse roles in embryonic development and the regulation of adult stem cells. It promotes proliferation of hematopoietic stem cells and can both activate and repress apoptosis.

Supplier: HexArmor

Safety eyewear should never be treated as one size fits all. Simply wearing any generic pair of safety eyewear isn’t enough to protect the eyes.Dual-injection soft-grip side arms for comfort and non-slip fit.

Supplier: Bioss

HOXB4 is a homeodomain-containing transcription factor with diverse roles in embryonic development and the regulation of adult stem cells. It promotes proliferation of hematopoietic stem cells and can both activate and repress apoptosis.

Supplier: Bioss

HOXB4 is a homeodomain-containing transcription factor with diverse roles in embryonic development and the regulation of adult stem cells. It promotes proliferation of hematopoietic stem cells and can both activate and repress apoptosis.

Supplier: Bioss

HOXB4 is a homeodomain-containing transcription factor with diverse roles in embryonic development and the regulation of adult stem cells. It promotes proliferation of hematopoietic stem cells and can both activate and repress apoptosis.

Supplier: HexArmor

Safety eyewear should never be treated as one size fits all. Simply wearing any generic pair of safety eyewear isn’t enough to protect the eyes.

Supplier: Thermco

These high precision liquid-in-glass mercury thermometers are hand blown, which bear graduations, numbers and letters etched into the glass and filled with and inert gas above the mercury column

Supplier: Bel-Art Products, a Part of SP

Featuring a case to protect from breakage, these total immersion thermometers are a compact 160mm (6.3”), making them ideal for field studies, waste water treatment and any “on-the-go” applications

Supplier: Biolegend

PE anti-mouse H-2Dk [15-5-5]; Isotype: Mouse (C3H.SW) IgG2a, κ; Reactivity: Mouse k haplotype, Cross-reacts with H-2Kd and H-2f haplotypes. Does not cross react with other haplotypes (e.g., a, b, p, q, r, s).; Apps: FC; Size: 50 μg

Supplier: Biolegend

Purified anti-mouse H-2Dk [15-5-5]; Isotype: Mouse (C3H.SW) IgG2a, κ; Reactivity: Mouse k haplotype, Cross-reacts with H-2Kd and H-2f haplotypes. Does not cross react with other haplotypes (e.g., a, b, p, q, r, s).; Apps: FC, IP; Size: 500 μg

Supplier: Bel-Art Products, a Part of SP

FRIO-Temp® Thermometers are used to verify temperatures in freezers, refrigerators, incubators and ovens with traceability to most ILAC standards.

Supplier: Bel-Art Products, a Part of SP

These environmentally safe thermometers are PFA safety coated to keep liquid and glass contained in the event of breakage.

Supplier: Biosensis

The heat shock proteins were discovered, as the name suggests, since they are heavily upregulated when cells are stressed by temperatures above the normal physiological range. They are expressed in unstressed cells also and have a normal function as chaperones, helping other proteins to fold correctly, and are required in much greater amounts if the cell or tissue is stressed by heat. The increased levels are generated transcriptionally under the influence of a powerful transcription factor, the heat shock factor 1 (HSF1). The different heat shock proteins were originally named based on their SDS-PAGE mobility, so HSP27 has an apparent molecular weight of 27kDa. It is an abundant protein even under non-stress conditions and frequently shows up as a major spot on 2 dimensional gels of cells or tissues. It is known to associate with a variety of other proteins such as actin, intermediate filament subunits and ubiquitin and is found both in the cytoplasm and the nucleus of cells. HSP27 can become heavily phosphorylated under the influence of multiple protein kinases particularly as a result of activation of the p38/SAPK pathway. Upregulation of this protein is protective against neurodegenerative diseases at least in certain mouse models (1). Point mutations in the HSP27 gene are associated with two neurological diseases, Charcot-Marie-Tooth disease type 2F and distal hereditary motor neuropathy IIB (2). These diseases are associated with axonal loss apparently following defects in the transport of neurofilaments.