5851 Results for: "Diaion® sk1 (Na)"

CD8a (clone SK1) is a mouse monoclonal antibody derived from the CD8 alpha chain. This antibody belongs to the Biotium Choice list of select antibodies that have been validated and optimized in-house for optimal performance. The antibody is available conjugated to CF® Dyes and Astral™ tandem dyes. They are supplied in PBS, 0.1% BSA, 0.05% azide.

CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

As an isotype control, Biotium recommend Isotype Control, Monoclonal Mouse IgG1 Kappa (IGG1/1331) for this antibody.

Expand 2 Items

Anti-CD8A Mouse Monoclonal Antibody (violetFluor® 450) [clone: SK1]

Supplier: Tonbo Biosciences

The SK1 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.

Expand 3 Items

Anti-CD8 Mouse Monoclonal Antibody [clone: SK1] (Spark Blue™ 550)

Supplier: Biolegend

CD8, Monoclonal Antibody, Clone: SK1, Host: Mouse, Species Reactivity: Human, Cross-Reactivity: African Green, Chimpanzee, Cynomolgus, Pigtailed Macaque, Rhesus, Sooty Mangabey, Isotype: IgG1, Conjugate: Spark Blue 550, Other Names: T8, Leu2, Application: FC, Size: 25 Tests

Expand 1 Items

Anti-CD8 Mouse Monoclonal Antibody (Biotin) [clone: SK1]

Supplier: Biolegend

Biotin anti-human CD8 [SK1]; Isotype: Mouse IgG1, κ; Reactivity: Human, Cross-Reactivity: African Green, Chimpanzee, Cynomolgus, Pigtailed Macaque, Rhesus, Sooty Mangabey; Apps: FC, IHC; Size: 100 μg

Expand 1 Items

Anti-CD8 Mouse Monoclonal Antibody (PerCP (Peridinin-Chlorophyll Protein Complex)) [clone: SK1]

Supplier: Biolegend

PerCP anti-human CD8 [SK1]; Isotype: Mouse IgG1, κ; Reactivity: Human, Cross-Reactivity: African Green, Chimpanzee, Cynomolgus, Pigtailed Macaque, Rhesus, Sooty Mangabey; Apps: FC; Size: 100 tests