891 Results for: "Diagnostic Biosystems"

Supplier: Diagnostic Biosystems

This buffer is a concentrated antigen unmasking solution and is free from heavy metals

Supplier: Diagnostic Biosystems

Clone124 .5Ml

Supplier: Diagnostic Biosystems

This kit stains Helicobacter pylori bacteria in paraffin tissue sections

Supplier: Diagnostic Biosystems

This antibody recognizes cytokeratin polypeptides ranging from 40 through 58kDa, corresponding to cytokeratins 5, 6, 8,17 and 19. It shows a broad pattern of reactivity with human epithelial tissues from simple glandular epithelia to stratified squamous epithelia, like epidermis, mammary gland ducts and tracheal epithelium.

Supplier: Diagnostic Biosystems

Anti-IgG Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Supplier: Diagnostic Biosystems

Anti-Neurofilaments Mouse Monoclonal Antibody [clone: 2F11]

Supplier: Diagnostic Biosystems

Chromogranin A is a 439 amino acid protein present in secretory granules of a wide variety of endocrine cells and neurons. A positive staining is seen in the secretory granules of parathyroid, adrenal medulla, anterior pituitary gland and Langerhans islets of pancreas. This antibody stains a variety of neuroendocrine tumors.

Supplier: Diagnostic Biosystems

This antibody reacts with the heavy chain present in all types of human IgM. It stains B cell follicles in human lymphoid tissues. In lymphoid tissues, IgM containing plasma cells stain strongly but immune complexes are usually undetectable.

Supplier: Diagnostic Biosystems

This antibody is specific against an epitope located on the β chain (i.e., in S-100a and S-100b) but not on the α chain of S-100 (i.e., in S-100a and S-100ao). This antibody can be used to localize S-100a and S-100b in various tissue sections.

Supplier: Diagnostic Biosystems

Rabbit .5Ml

Supplier: Diagnostic Biosystems

Clonejc/70A .5Ml

Supplier: Diagnostic Biosystems

Anti-F8 Mouse Monoclonal Antibody [clone: F8/86]

Supplier: Diagnostic Biosystems

The CD163 molecule is a type I membrane protein also known as M130 antigen, Ber-MAC3, Ki-M8 or SM4. CD163 protein is restricted in its expression to the monocytic/macrophage lineage. It is reported to be present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells and Langerhans cells. In addition, multinucleated cells within inflammatory lesions are reported not to express CD163 protein. The protein is upregulated by glucocorticoids and downregulated by the immunosuppressant cyclosporin A and by phorbol esters.

Supplier: Diagnostic Biosystems

Cyclin D1 belongs to the Cyclin D family. Cyclin D1 is required for the cell cycle G1/S transition. Amplification or overexpression of Cyclin D1 plays a pivotal role in the development of various human cancers including breast cancer, colon cancer, melanoma, prostate cancer, and lymphoma. It is useful to differentiate mantle cell lymphoma from small cleaved cell lymphoma. Rabbit monoclonal antibodies to Cyclin D1 showed the highest sensitivity to detect this antigen in formalin fixed paraffin embedded tissue as compared to several other clones.

Supplier: Diagnostic Biosystems

This antibody recognizes Chromogranin A. Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

Supplier: Diagnostic Biosystems

This antibody recognizes keratin polypeptide of 54 kDa. It stains a number of epithelial cells including ductal and glandular epithelia. Stratified squamous epithelia are positive but transitional epithelium of the urinary tract does not show any staining. This antibody labels adenocarcinomas and transitional carcinomas but does not react with squamous cell carcinomas.

Supplier: Diagnostic Biosystems

The G168-15 antibody recognizes human and mouse MLH1 (80-85kDa). The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.

Supplier: Diagnostic Biosystems

Anti-CD23 Rabbit Monoclonal Antibody [clone: SP23]

Supplier: Diagnostic Biosystems

Rabbit .5Ml

Supplier: Diagnostic Biosystems

This antibody reacts with the c-erbB-2 oncoprotein, a 190 kDa protein. The proto-oncogene for c-erbB-2 is located on the human chromosome 17, band 21. It has structural similarities to EGFR. Several studies have indicated that c-erbB-2 may be a good indicator of the prognosis of human carcinomas in the breast, ovary, uterus and gastrointestinal tract.

Supplier: Diagnostic Biosystems

Cytokeratin 20 is less acidic than the other type I cytokeratins and is of particular interest because of its restricted range of expression. This antibody reacts with cytokeratin polypeptide of 46 kDa in immunoblot analyses. Studies have shown that a marked difference exists in the expression of Cytokeratin 20 among various carcinomas.

Supplier: Diagnostic Biosystems

Anti-CTSD Rabbit Polyclonal Antibody

Supplier: Diagnostic Biosystems

This antibody recognizes a c-erbB-2 protein, which is a receptor tyrosine kinase of the c-erbB family. It is closely related in structure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a subset of breast and other adenocarcinomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.

Supplier: Diagnostic Biosystems

This antibody is specific to γ-γ enolase isozyme of 46 kDa. This antibody stains neurons, neuroendocrine cells, gangliomas, oat cell carcinomas, astrocytomas, paragangliomas, glioblastomas, pheochromocytomas, melanomas and schwannomas.

Supplier: Diagnostic Biosystems

Wilms tumor-1 (WT-1), is a gene involved in the induction of Wilms tumor, a pediatric renal malignancy. Wilms tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilms tumor and mesothelioma.

Supplier: Diagnostic Biosystems

Anti-CD20 Mouse Monoclonal Antibody [clone: L26]

Supplier: Diagnostic Biosystems

This antibody reacts with free as well as bound kappa light chains. Contaminating antibodies have been removed by solid phase adsorption.

Supplier: Diagnostic Biosystems

This antibody recognizes keratin polypeptides of 68, 58, 56.5 and 50 kDa in the stratum corneum. The antibody reacts with squamous, ductal and other complex epithelia. It stains adenocarcinomas, breast, pancreas, bile duct, salivary gland and transitional cell carcinomas.

Supplier: Diagnostic Biosystems

Anti-CD1A Cortical Thymocytes Antibody

Supplier: Diagnostic Biosystems

Anti-Gastrin Rabbit Polyclonal Antibody