891 Results for: "Diagnostic Biosystems"

Supplier: Diagnostic Biosystems

This antibody recognizes insoluble elastin, α-elastin, soluble non-cross linked precursor of elastin (tropoelastin). Elastin is an important polymeric protein of connective tissue that imparts elasticity to vertebrate elastic tissues.

Supplier: Diagnostic Biosystems

This antibody is specific to human CD79a antigen complex, consisting of two polypeptides non-covalently associated with membrane-bound immunoglobulins on B cells. This complex of polypeptide and immunoglobulins constitute the B cell antigen receptor. The two components of this complex are designated CD79a and CD79b. The CD79a antigen appears at the pre-B cell stage, early in maturation and persists until the plasma cell stage. The CD79a antigen is found in majority of acute leukemias of precursor B cell type, in B cell lines and B cell lymphomas.

Supplier: Diagnostic Biosystems

This antibody is specific to a protein of 27 kDa known as p27Kip1 a cell cycle regulatory mitotic inhibitor. This antibody recognizes an epitope between amino acids 83-204 of p27. This antibody does not show any cross-reactivity with other related mitotic inhibitors.

Supplier: Diagnostic Biosystems

This antibody reacts with wild as well as mutant types of P53 protein. It recognizes an epitope in the N-terminus of p53 protein, known to reside between amino acids 35 to 45. This antibody can be demonstrated in 22 to 76% of the colon, stomach, bladder, breast, lung and testes cancers.

Supplier: Diagnostic Biosystems

This antibody is specific against an epitope located on the β chain (i.e. in S-100a and S-100b) but not on the α chain of S-100 (i.e. in S-100a and S-100ao). This antibody can be used to localize S-100a and S-100b in various tissue sections.

Supplier: Diagnostic Biosystems

Anti-PSA Rabbit Polyclonal Antibody

Supplier: Diagnostic Biosystems

Anti-CASP8 Rabbit Polyclonal Antibody

Supplier: Diagnostic Biosystems

Clone2B11+Pd7/26 .5Ml

Supplier: Diagnostic Biosystems

This antibody is specific to a 32 kDa protein, which is identified as Caspase 3. Caspase 3 is associated with induction of apoptosis. Caspase 3 is ubiquitously expressed and is synthesized as an inactive proenzyme.

Supplier: Diagnostic Biosystems

This antibody reacts with P. carinii in the fixed human tissues. The antibody is specific against an 82 kDa parasite specific polypeptide. It does not cross-react with G. lamblia, T. gondii, T. cruzi, L. tropica, E. histolytica, C. albicans and P. falciparum.

Supplier: Diagnostic Biosystems

This antibody is specific to erythroid cells at various stages of differentiation from the erythroblast to the mature red cell.

Supplier: Diagnostic Biosystems

ImmunoHisto-Sealer™ is a preservation solution that acts as a sealant to improve tissue morphology and stain over an extended period of time. When applied to the stained section, specimens can be permanently mounted without chromogens fading. Additional benefits of the ImmunoHisto-Sealer™ include: saves hands on time when mounting slides, avoids the use of toxic chemicals such as xylene and eliminates accumulation of hazardous waste. This product is designed for tissue specimens stained with peroxidase, alkaline phosphatase-based systems and various chromogens. After treating with ImmunoHisto-Sealer, water solution chromogens can be mounted in Permanent Mounting Media

Supplier: Diagnostic Biosystems

CD138, also known as Syndecan-1, is a member of the transmembrane heparan sulfate proteoglycan family, acts as an extracellular matrix receptor and is involved in many cellular functions, including cell-cell adhesion and cell-matrix adhesion. CD138 expression is found in both hematopoietic and non-hematopoietic cells. In the hematopoietic system, CD138 labels plasma cells. It is an excellent marker for plasmacytic differentiation within the spectrum of hematologic malignancy. Among non-hematolymphoid cells, CD138 reactivity is observed in many types of epithelial cells and stoma cells in both normal and tumor tissues.

Supplier: Diagnostic Biosystems

This antibody reacts with a 55 kDa protein. Caspase 8 has an N-terminal domain with sequence homology to the death effector domain (DED) of FADD. Caspase 8 binds to DED of FADD. Caspase 8 is activated by association with Fas/FADD death-inducing signaling complex to release two active subunits, P18 and P10 into the cytosol, where they activate other caspases amplifying the apoptotic signal.

Supplier: Diagnostic Biosystems

This antibody recognizes most of the acidic (Type I) keratins. It recognizes keratin polypeptides of 50 and 56.5 kDa. In keratinized epidermis, 50 kDa keratin is present in the basal layer, while 56.5 kDa keratin is present in suprabasal layers.

Supplier: Diagnostic Biosystems

The BCL6 gene encodes a 706 amino acid nuclear protein of the Kruppeltype zinc finger protein. It is rearranged in about 30% of diffuse large B-cell lymphomas, and is expressed predominantly in normal germinal centre B cells and related lymphomas. The antibody is a useful aid for classification of follicular lymphomas, diffuse large B-cell lymphomas, Burkitt's lymphomas, and nodular, lymphocyte-predominance Hodgkin's lymphoma. The BCL6 antibody, together with BCL2 antibody, is also a useful aid in classification of mantle cell lymphomas, and nodular, lymphocytepredominance Hodgkin's lymphoma. BCL6 protein is not expressed in BCLL, hairy cell leukemia, mantle cell and marginal-zone derived lymphomas.

Supplier: Diagnostic Biosystems

This antibody recognizes thyroglobulin in hyperplastic and neoplastic thyroid. Thyroglobulin is a protein of 670 kDa consisting of two identical subunits. Thyroglobulin is synthesized by the follicular epithelial cells of the thyroid.

Supplier: Diagnostic Biosystems

Anti-CD10 Mouse Monoclonal Antibody [clone: 56C6]

Supplier: Diagnostic Biosystems

Anti-MYOG Mouse Monoclonal Antibody [clone: F5D]

Supplier: Diagnostic Biosystems

Anti-MUM1 Mouse Monoclonal Antibody [clone: MUM1p]

Supplier: Diagnostic Biosystems

Clonecub7402 .5Ml

Supplier: Diagnostic Biosystems

Anti-ITGB3 Mouse Monoclonal Antibody [clone: Y2/51]

Supplier: Diagnostic Biosystems

Complement 4d (C4d) is the most clinically used marker for humoral rejection. It is a degradation product of the activated complement factor C4b. Complement 4d is typically initiated by binding of antibodies to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. Complement 4d is also found in intracytoplasmic vacuoles of endothelial cells. Covalent binding renders C4d a stable molecule that can easily be detected by immunohistochemistry.

Supplier: Diagnostic Biosystems

This antibody is specific to an oncofetal antigen of >1000 kDa known as tumor associated glycoprotein (TAG-72) or CA 72-4. This antibody defines the mucin carried sialylated-Tn antigen. This antibody stains the majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary and non-small cell lung cancer.

Supplier: Diagnostic Biosystems

This antibody is specific to a 55 kDa protein known as interleukin 2-receptor α (IL-2R α). IL-2R α is over expressed on the surface of activated T cells, HTLV-1 or HTLV-2 positive T cell lines and moderately expressed on activated B cells, NK-cells and macrophages.

Supplier: Diagnostic Biosystems

This antibody is specific to bcl-2 oncoprotein, encoded by a gene involved in the 14;18 chromosomal translocation. In lymphoid tissues, this antibody stains B lymphocytes as well as T cells.

Supplier: Diagnostic Biosystems

This antibody reacts with HSV type I and II specific antigens and with antigens common to HSV type I and II virus. It reacts with all the major glycoproteins present in the viral envelope as well as with at least one core protein.

Supplier: Diagnostic Biosystems

Rabbit .5Ml

Supplier: Diagnostic Biosystems

Anti-Cytokeratin 5/14 Mouse Monoclonal Antibody [clone: XM26 + LL002]

Supplier: Diagnostic Biosystems

Neurotrophic tyrosine kinase receptor (NTRK) is a family of 3 proto-oncogenes including NTRK1, NTRK2, and NTRK3 which encode Trk A, Trk B, and Trk C proteins, respectively. The latter are involved in biological processes such as neuronal survival, differentiation, and plasticity under physiological circumstances. In various cancers, oncogenic fusions involving the kinase domain of NTRK1, 2, or 3 are present. Pan-Trk IHC is a time- and tissue-efficient screen for NTRK fusions, particularly in drivernegative advanced malignancies and potential cases of secretory carcinoma and congenital fibrosarcoma. Pan-Trk IHC can help determine whether translation occurs for novel NTRK rearrangements.