9079 Results for: "2-Bromo-4,5-difluorotoluene"
Protector® ClassMate™ Laboratory Hoods, Labconco®
Supplier: Labconco
ClassMate™ laboratory hoods are designed to meet the needs of instructional laboratories.
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BoneClones® Animal Skulls, Primates
Supplier: BONE CLONES, INC.
Replicas of real specimens.
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Anti-CD40 Rabbit Polyclonal Antibody
Supplier: Genetex
CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.
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FOCUS: SAFETY - OUT NOW!
Let’s enhance safety by considering personalized protection equipment (PPE) solutions tailored to your team, processes, and products.
Makers Steam Cart
Supplier: KIDDER MFG. CO. LTD
This mobile steam makers cart is a must have for your schools and classroom!
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Anti-LAP2 Mouse Monoclonal Antibody [clone: 6E10]
Supplier: Genetex
Lamins are type V intermediate filament proteins and are grouped into constitutively expressed B-type lamins and developmentally regulated A-type lamins. Lamin-binding proteins in the nuclear lamina and the nuclear interior include several protein families and/or types of proteins in higher eukaryotes such as the inner nuclear membrane proteins, lamin B receptor, emerin, and MANI, three isoforms of lamina-associated polypeptide 1 (LAP1), and several isoforms of LAP2. Up to six LAP 2 isoforms derive from a single gene by alternative splicing in mammals and various isoforms have been described in Xenopus. The best characterized LAP2 isoforms are the inner nuclear membrane protein LAP2 beta and the nucleoplasmic protein LAP2 alpha, which are identical in their N-terminal 187-amino acid constant region but differ in their C termini. While LAP2 beta binds to B-type lamins at the nuclear periphery and was suggested to regulate nuclear lamina growth , LAP2 alpha specifically interacts with A-type lamins within the nuclear interior as part of a detergent/salt-resistant nucleoskeletal structure.
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BS-480 Chemistry Analyzer, without ISE Module, MedTest DX
Supplier: MEDTEST DX, INC.
The MedTest 480 Ensemble provides exceptional value and convenience by bringing together everything your mid-volume laboratory needs to perform clinical chemistry testing
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CyBio® FeliX Automated Pipet Robots, Analytik Jena US
Supplier: Analytik Jena CA
Flexible pipetting platform for fully automated single to multichannel liquid handling.
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Short™ AE-IGF-1 Human Insulin Like Growth Factor
Supplier: CELLRX LIMITED
Short™ AE-IGF-1 is a recombinant protein of human insulin-like growth factor-I (IGF-1) that has been engineered with an N-terminal Ala-Glu sequence, enabling higher specific activity versus IGF-1 over a longer time course in small to large-scale culture systems and bioreactors. It is approximately 100-fold more biologically potent, in-vitro, than insulin and significantly increases recombinant protein production while reducing apoptosis. Short™ AE-IGF-1 is produced and tested under ISO 9001, ISO 14001, ISO 45001 accreditation, fully defined animal-free components. It is liquid stable, high purity with requisite performance at a compelling price.
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E1-ClipTip® Equalizer Adjustable Tip Spacing Multichannel Pipettors with Bluetooth Capability, Thermo Scientific
Supplier: Thermo Scientific
Perform sample transfers between virtually any tube, rack, microplate or horizontal gel box quickly and efficiently with adjustable tip spacing.
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Gel/PCR DNA Fragment Extraction Kits (Large and Small Fragment), IBI Scientific
Supplier: IBI Scientific
The Large DNA Fragment Extraction Kits are designed to recover large DNA fragments (>8Kb) from an agarose gel
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Anti-CDC45 Rabbit Polyclonal Antibody
Supplier: Prosci
CDC45L was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
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Moxi GO II™ 488 Cell QC Analyzer
Supplier: Orflo
Moxi GO II™ combines two instruments to deliver amazingly affordable, easy to use, maintenance-free, gold standard cell count accuracy and precision through the Coulter Principle and integrating 2 channels of flow cytometry. This unique combination covers a large number of routine cell assays (cell count, cell volume, viability, cell proliferation, transfection checks, apoptosis, phenotyping, cellular response) with quantitative single cell data output.
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Synthetic Nanodisc Screening Kit MINI
Supplier: CUBE BIOTECH
Synthetic copolymers are capable of solubilizing and stabilizing membrane proteins without the need for detergents. They have the unique capacity to extract the membrane protein of interest while maintaining a near-native environment.
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CytoFLEX SRT Bench Top Cell Sorter, Beckman Coulter
Supplier: Beckman Coulter
If you need an approachable instrument for sorting multiple populations to generate high quality material for downstream assays, the CytoFLEX SRT benchtop cell sorter is quick to learn and easy to operate. This extension of the CytoFLEX platform is built on the same optical features as the flow cytometer, but equally important, it continues to adhere to the principles that made multicolor applications accessible to many biomedical research, core research, pharma and biotechs.
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Laboratory Glassware Washers, Model PLW 8617, Miele
Supplier: Miele
The PLW 8617 laboratory washer can accommodate 216 laboratory flasks, 588 vials, or 294 pipettes. The large glassware washer is flexible and simple to use, it has modular load carriers and SimpleLoad system. This efficient unit has a single door, 1150 mm (3' 91/4") wide, a usable capacity of 351 litres. PLW 8617 provides reliable results, high pump performance with a variable-speed pump and features spray arm monitoring and a conductivity meter.
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BoneClones® Animal Skulls, Mammals
Supplier: BONE CLONES, INC.
Expand Your Animal Skull Options
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Pierce™ Immunoprecipitation, Magnetic ChIP Kit, Thermo Scientific
Supplier: Thermo Scientific
The Pierce™ Magnetic ChIP Kit provides a convenient method for efficient isolation of chromatin-bound DNA by immunoprecipitation for subsequent quantitation by PCR.
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blackPREP Rodent Tail DNA Kit, Analytik Jena
Supplier: Analytik Jena CA
The blackPREP Rodent Tail DNA Kit has been specially optimized for isolating DNA from pieces of mouse and rat tails, guaranteeing extremely high yields in a very short period of time (typically 3 hours or less).
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Anti-SMARCB1 Rabbit Polyclonal Antibody
Supplier: Genetex
Chromatin, the physiological packaging structure of histone proteins and DNA, is considered a key element in regulating gene expression. Several complexes involved in transcriptional regulation function by either modifying histones or altering chromatin structure. Postranslational modifications of histones, such as acetylation, phosphorylation and methylation, contribute to the regulation of transcription. The ATP-dependent chromatin-remodeling complexes alter chromatin structure by using the energy of ATP hydrolysis to locally disrupt the association of histones with DNA, displacing the nucleosomes from promoter and enhancer regions, and therefore allowing transcription initiation. Chromatin remodeling complexes have been purified from a variety of organisms, and most cell types contain more than one type of complex. These complexes contain structurally related catalytic subunits, but differ in the way in which they manipulate chromatin. Three families of complexes have been described the SWI/SNF family, ISWI family, and Mi-2 family. The SWI/SNF family of ATP-dependent remodeling complexes was identified in yeast, drosophila, and human. It causes nucleosomes to change structure and/or position in order to allow transcriptional activators to gain access to their target sites. The SWI/SNF complex was originally identified in yeast as a 2 MDa complex, later shown to be highly conserved in all eukaryotes. Components of the hSWI/SNF complexes have been implicated in a range of cellular events including gene activation, regulation of cell growth, and development. The human homologue of yeast SNF5, SMARCB1, was identified in a two-hybrid screening performed to identify binding targets of the integrase of HIV, and the gene called INI1. Many studies have indicated that yeast SNF and its human counterparts are able to interact with sequence-specific transcription factors, which may recruit the complex to specific genes. For example, it has been shown that SMARCB1 interacts with the protooncogene c-Myc and the SWI complex is necessary for c-Myc mediated transactivation. Mutations in SNF5 and Brg1, both SWI components, suggest a connection of the complex with cancer. In fact, SMARCB1 displays properties of a tumor-suppressor gene, as sporadic rhabdoid tumors show biallelic loss-of-function mutations, and germline mutations confer and autosomal-dominant syndrome that predisposes patients to a variety of rhabdoid cancers.