9071 Results for: "2-Bromo-4,5-dichloroimidazo"
CyBio® FeliX Automated Pipet Robots, Analytik Jena US
Supplier: Analytik Jena CA
Flexible pipetting platform for fully automated single to multichannel liquid handling.
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CytoFLEX SRT Bench Top Cell Sorter, Beckman Coulter
Supplier: Beckman Coulter
If you need an approachable instrument for sorting multiple populations to generate high quality material for downstream assays, the CytoFLEX SRT benchtop cell sorter is quick to learn and easy to operate. This extension of the CytoFLEX platform is built on the same optical features as the flow cytometer, but equally important, it continues to adhere to the principles that made multicolor applications accessible to many biomedical research, core research, pharma and biotechs.
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Gel/PCR DNA Fragment Extraction Kits (Large and Small Fragment), IBI Scientific
Supplier: IBI Scientific
The Large DNA Fragment Extraction Kits are designed to recover large DNA fragments (>8Kb) from an agarose gel
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Anti-CDC45 Rabbit Polyclonal Antibody
Supplier: Prosci
CDC45L was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
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Synthetic Nanodisc Screening Kit MINI
Supplier: CUBE BIOTECH
Synthetic copolymers are capable of solubilizing and stabilizing membrane proteins without the need for detergents. They have the unique capacity to extract the membrane protein of interest while maintaining a near-native environment.
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Moxi GO II™ 488 Cell QC Analyzer
Supplier: Orflo
Moxi GO II™ combines two instruments to deliver amazingly affordable, easy to use, maintenance-free, gold standard cell count accuracy and precision through the Coulter Principle and integrating 2 channels of flow cytometry. This unique combination covers a large number of routine cell assays (cell count, cell volume, viability, cell proliferation, transfection checks, apoptosis, phenotyping, cellular response) with quantitative single cell data output.
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Laboratory Glassware Washers, Model PLW 8617, Miele
Supplier: Miele
The PLW 8617 laboratory washer can accommodate 216 laboratory flasks, 588 vials, or 294 pipettes. The large glassware washer is flexible and simple to use, it has modular load carriers and SimpleLoad system. This efficient unit has a single door, 1150 mm (3' 91/4") wide, a usable capacity of 351 litres. PLW 8617 provides reliable results, high pump performance with a variable-speed pump and features spray arm monitoring and a conductivity meter.
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BoneClones® Animal Skulls, Mammals
Supplier: BONE CLONES, INC.
Expand Your Animal Skull Options
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Pierce™ Immunoprecipitation, Magnetic ChIP Kit, Thermo Scientific
Supplier: Thermo Scientific
The Pierce™ Magnetic ChIP Kit provides a convenient method for efficient isolation of chromatin-bound DNA by immunoprecipitation for subsequent quantitation by PCR.
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blackPREP Rodent Tail DNA Kit, Analytik Jena
Supplier: Analytik Jena CA
The blackPREP Rodent Tail DNA Kit has been specially optimized for isolating DNA from pieces of mouse and rat tails, guaranteeing extremely high yields in a very short period of time (typically 3 hours or less).
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Anti-SMARCB1 Rabbit Polyclonal Antibody
Supplier: Genetex
Chromatin, the physiological packaging structure of histone proteins and DNA, is considered a key element in regulating gene expression. Several complexes involved in transcriptional regulation function by either modifying histones or altering chromatin structure. Postranslational modifications of histones, such as acetylation, phosphorylation and methylation, contribute to the regulation of transcription. The ATP-dependent chromatin-remodeling complexes alter chromatin structure by using the energy of ATP hydrolysis to locally disrupt the association of histones with DNA, displacing the nucleosomes from promoter and enhancer regions, and therefore allowing transcription initiation. Chromatin remodeling complexes have been purified from a variety of organisms, and most cell types contain more than one type of complex. These complexes contain structurally related catalytic subunits, but differ in the way in which they manipulate chromatin. Three families of complexes have been described the SWI/SNF family, ISWI family, and Mi-2 family. The SWI/SNF family of ATP-dependent remodeling complexes was identified in yeast, drosophila, and human. It causes nucleosomes to change structure and/or position in order to allow transcriptional activators to gain access to their target sites. The SWI/SNF complex was originally identified in yeast as a 2 MDa complex, later shown to be highly conserved in all eukaryotes. Components of the hSWI/SNF complexes have been implicated in a range of cellular events including gene activation, regulation of cell growth, and development. The human homologue of yeast SNF5, SMARCB1, was identified in a two-hybrid screening performed to identify binding targets of the integrase of HIV, and the gene called INI1. Many studies have indicated that yeast SNF and its human counterparts are able to interact with sequence-specific transcription factors, which may recruit the complex to specific genes. For example, it has been shown that SMARCB1 interacts with the protooncogene c-Myc and the SWI complex is necessary for c-Myc mediated transactivation. Mutations in SNF5 and Brg1, both SWI components, suggest a connection of the complex with cancer. In fact, SMARCB1 displays properties of a tumor-suppressor gene, as sporadic rhabdoid tumors show biallelic loss-of-function mutations, and germline mutations confer and autosomal-dominant syndrome that predisposes patients to a variety of rhabdoid cancers.