42168 Results for: "1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-mu-hydrotetracarbonyldiruthenium(II)"

Supplier: Thermo Scientific Chemicals

1,2,3,4-Tetramethylcyclopentadiene mixture of isomers tech. 85%, tech.

Supplier: MilliporeSigma

Supplier: TCI America

CAS Number: 93379-48-7
MDL Number: MFCD00064467
Molecular Formula: C31H30O4
Molecular Weight: 466.58
Purity/Analysis Method: >97.0% (HPLC)
Form: Crystal
Melting point (°C): 196
Specific rotation [a]20/D: -69 deg (C=1, CHCl3)

Supplier: TCI America

CAS Number: 632-51-9
MDL Number: MFCD00004764
Molecular Formula: C26H20
Molecular Weight: 332.45
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Color: White
Melting point (°C): 225

Supplier: MilliporeSigma

Supplier: Thermo Scientific Chemicals

Sudan II

Supplier: Thermo Scientific Chemicals

Manganese (II) acetylacetonate

Supplier: Thermo Scientific Chemicals

Trimethyl(methylcyclopentadienyl)platinum(IV)

Supplier: Thermo Scientific Chemicals

MDL: MFCD00000016

Supplier: TCI America

CAS Number: 14781-45-4
MDL Number: MFCD00064754
Molecular Formula: C10H2CuF12O4
Molecular Weight: 477.65
Purity/Analysis Method: >95.0% (T)
Form: Crystal

Supplier: MilliporeSigma

1,2,3,4,5-Pentamethylcyclopentadiene, CAS Number: 4045-44-7, for synthesis.

Supplier: Enzo Life Sciences

The GST Family
Glutathione S-transferases (GSTs) are a large multigen family of multifunctional enzymes, which play an important role in detoxification of potentially genotoxic chemicals, by catalyzing the conjugation of glutathione to a large number of hydrophobic and electrophilic compounds, including carcinogens. They also bind to a variety of nonsubstrate ligands. The GSTs are widely distributed in mammalian species and can be grouped into four classes, based on their biochemical, immunological and structural properties: alpha, mu, pi and theta.

GSTs are dimeric, mainly cytosolic, enzymes that have extensive ligand binding properties in addition to their catalytic role in detoxification. A separate microsomal class of GSTs exists which is quite distinct from the cytosolic GSTs, and is designated as "membrane-associated proteins in eicosanoid and glutathione metabolism" (MAPEG). The N-terminal region tends to be better conserved within classes as it includes an important part of the active site.GSTs are believed to play a role in cancer prevention, as the electrophilic compounds that are conjugated to glutathione could otherwise react with and modify cellular components such as DNA, thereby initiating carcinogenesis. On the other hand, GSTs might detoxify chemotherapeutic drugs in cancer cells, thus contributing to drug resistance.
In summary, GSTs are a group of enzymes which are centrally involved in drug metabolism and detoxification. Because of their role in detoxification, they have been implicated in drug sensitivity and resistance. They may also influence mutagenesis and carcinogenesis and thus, increased GST activity may become a useful cancer marker.
Since many GST genes are polymorphic, there has been considerable interest in determining whether particular allelic variants are also associated with an increase of risk for certain diseases.

Glutathione S-transferase-Pi
The GST-Pi class (phase II detoxification enzymes) is the most abundant of the human glutathione S-transferases family, a major group of detoxification enzymes and widely distributed in the human body.
In normal human tissues, the enzymes protect cells against reactions with glutathione and reactive oxygen species by reducing organic hydroperoxides via gluthathione peroxidase activity.
The role of GST-Pi in tumor growth and progression is less well known. It is reported to be variably expressed in breast cancer and is associated with estrogen receptor levels expressed by the tumor. Down-regulation of GST-Pi activity in a study done on a T cell line appears to favor apoptosis and inhibition of GST-Pi function induces apoptosis in rat hepatoma cells.
The importance in cancer research is clear, as GST-Pi has been implicated in protection against apoptosis and also suggested to have a role in jun kinase inhibition.
The majority of human tumor cell lines express significant amounts of class pi GST, which is why it is being investigated as a potential marker for various types of cancer. GST-Pi is thought to be associated with increased resistance to anticancer drugs. GST-Pi expression is under investigation as a prognostic indicator for resistance to chemotherapy and a marker of treatment resistance.

Supplier: TCI America

CAS Number: 16092-38-9
MDL Number: MFCD00044994
Molecular Formula: C10H8CoF6O4
Molecular Weight: 365.09
Purity/Analysis Method: >90.0% (T)
Form: Crystal
Color: Yellow

Supplier: Avantor Fluid Handling

Easy stack multiple pump heads on your Masterflex® L/S® drive.

Supplier: TCI America

CAS Number: 123334-29-2 MDL Number: MFCD00000014 Molecular Formula: C10H14CoO4 Molecular Weight: 257.15 Purity/Analysis Method: 98.0% (T) Form: Crystal

Supplier: Thermo Scientific Chemicals

Soluble in methanol, acetone, toluene

Supplier: TCI America

[Spectrophotometric reagent for Mg]
CAS Number: 523-67-1
MDL Number: MFCD00014309
Molecular Formula: C25H21N3O3
Molecular Weight: 411.46
Purity/Analysis Method: >95.0% (HPLC)
Form: Crystal
Melting point (°C): 247

Supplier: Thermo Scientific Chemicals

1,2,3,4,5-Pentamethylcyclopentadiene 94%

Supplier: MilliporeSigma

Supplier: TCI America

CAS Number: 3118-97-6
MDL Number: MFCD00003896
Molecular Formula: C18H16N2O
Molecular Weight: 276.34
Purity/Analysis Method: >93.0% (E)
Form: Crystal
Melting point (°C): 160
Lambda max.: 498 nm (CHCl3)

Supplier: Thermo Scientific Chemicals

MDL: MFCD00011494 Beilstein Registry No.: 3599783

Supplier: TCI America

CAS Number: 14024-56-7
MDL Number: MFCD00013497
Molecular Formula: C10H14MgO4
Molecular Weight: 222.52
Purity/Analysis Method: >98.0% (T)
Form: Crystal
Melting point (°C): 276

Supplier: Thermo Scientific Chemicals

MDL: MFCD00000035 Soluble in alcohol. Slightly soluble in water

Supplier: TCI America

CAS Number: 19372-44-2
MDL Number: MFCD00013486
Molecular Formula: C10H14CaO4
Molecular Weight: 238.30
Purity/Analysis Method: >98.0% (T)
Form: Crystal

Supplier: Thermo Scientific Chemicals

Copper(II) hexafluoroacetylacetonate hydrate ≥99.99% (metals basis)

Supplier: TCI America

CAS Number: 14024-58-9
MDL Number: MFCD00000022
Molecular Formula: C10H14MnO4
Molecular Weight: 253.16
Purity/Analysis Method: >97.0% (T)
Form: Crystal

Supplier: Thermo Scientific Chemicals

meso-Tetraphenylporphine low chlorine

Supplier: Thermo Scientific Chemicals

Lead(II) acetylacetonate

Supplier: VWR International

High-precision unit is designed for years of reliable service, even in the most severe environments.

Supplier: Thermo Scientific Chemicals

MDL: MFCD00011494 Beilstein Registry No.: 3599783