42168 Results for: "1-hydroxytetraphenylcyclopentadienyl(tetraphenyl-2,4-cyclopentadien-1-one)-mu-hydrotetracarbonyldiruthenium(II)"
PMA™, PMAxx™, Real-Time PCR Viability Kit, Biotium
Supplier: Biotium
Viability PCR With PMA and PMAxx™ dyes
Expand 12 Items
Manual Slim Pen Cutter With Safety Blade, Slice®
Supplier: SLICE, INC.
The Slice® Manual Slim Pen Cutter uses the same finger-friendly® blade as our original pen cutters, offering the same safety benefits. Slice’s proprietary grind—applied to advanced ceramics—creates a unique edge that’s safe to the touch and lasts up to 11 times longer than comparable metal blades. The slim handle style allows maneuverability in tight spaces and features a side slider for easier manipulation with the thumb. As with all Slice tools, it can be used ambidextrously. Made from durable glass-filled nylon, the Manual Slim Pen Cutter offers two different cutting depths to suit a variety of cutting tasks.
Expand 1 Items
Anti-Leptin Rabbit Polyclonal Antibody
Supplier: Rockland Immunochemical
Leptin is a key player in the regulation of energy balance and body weight control. Once released into the circulation, it has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. It acts as an appetite-regulating factor, regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones, it increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, it induces FOS and SOCS3 expression to release anorexigenic peptides. It has a modulatory role in nutrient absorption. It reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. It acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. It may also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. It plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 which promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4+CD25- T cells proliferation and reduces autophagy during TCR (T cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.
Expand 1 Items
![313376_260x190.jpg](https://occapi.avantorsciences.com/medias/313376-260x190.jpg?context=bWFzdGVyfGltYWdlc3w5NDQ1fGltYWdlL2pwZWd8YURReUwyZzFZUzg1TnpBMk1ETTBOekkwT0RrMEx6TXhNek0zTmw4eU5qQjRNVGt3TG1wd1p3fGY0MjhiMmY1ZGJjNTY3NDdlZDk5ZjMwMGEyYTdmYjNkY2IyNWE2ZmI1MTg2YTM4MjE0MTY4MmNiYjVmNTViMTE)
Now Available: Our latest edition of elements!
Unlock innovation! Packed with products from both our leading suppliers and our exclusive Avantor® brands.
Celestron StarSense Explorer LT 114AZ Telescope
Supplier: Celestron International
StarSense Explorer is ideal for beginners thanks to the app’s user-friendly interface and detailed tutorials.
Expand 1 Items
Anti-IL7 Mouse Monoclonal Antibody [clone: NYR-hi7]
Supplier: Prosci
Iterleukin 7 is a lymphoid cell growth factor that affects pre-B, pro-B, and early T cells. IL-7 was previously known as pre-B cell growth factor and lymphopoietin 1. IL-7 supports the growth of early B cells from long-term lymphoid bone marrow cultures. It is mitogenic to thymocytes and enhances the response of cells to other stimuli such as polyhydroxyalkanoate (PHA) and concanavalin A (ConA). IL-7 stimulates the proliferation of CD4+/CD8+ cells. The proliferative response of thymocytes to IL-7 is not affected by antibodies to the T cell growth factors such as IL-2, IL-4 and IL-6, suggesting that IL-7 is capable of stimulating T cell proliferation through a pathway independent of the known T cell growth factors. Mature T cells respond to IL-7 and Con A, but not to IL-7 alone. In myeloid lineage cells, IL-7 upregulates the production of pro-inflammatory cytokines and stimulates the tumoricidal activity of monocytes/macrophages. IL-7 is expressed by adherent stromal cells from various tissues.
Expand 1 Items
Orion™ Star™ A214 pH/ISE Benchtop Meter, Thermo Scientific
Supplier: Thermo Fisher Scientific
Reliably measure pH, ion concentration, mV, ORP, and temperature with the Orion™ Star™ A214 pH/ISE Benchtop Meter for advanced laboratory analysis and interfacing.
Expand 5 Items
Anti-GABRA1 Rabbit Polyclonal Antibody
Supplier: Prosci
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA-Receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha and beta subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha subunits of the receptor. Lastly, phosphorylation of beta subunits of the receptor has been shown to modulate GABAA-R function.
Expand 1 Items
Purifier® Filtered PCR Enclosures, Labconco®
Supplier: Labconco
Enclosures provide a controlled environment in which to perform polymerase chain reaction (PCR) procedures
Expand 12 Items
E.Z.N.A.® RNA Isolation Kits, Omega Bio-Tek
Supplier: Omega Bio-Tek
Isolated RNA can be used for Northern blotting, RT-PCR, nuclease protection assays, in vitro translation, and microarray analysis
Expand 3 Items
Pierce™ Immunoprecipitation, Magnetic ChIP Kit, Thermo Scientific
Supplier: Thermo Scientific
The Pierce™ Magnetic ChIP Kit provides a convenient method for efficient isolation of chromatin-bound DNA by immunoprecipitation for subsequent quantitation by PCR.
Expand 1 Items
Anti-INCENP Rabbit Polyclonal Antibody
Supplier: Genetex
Chromosomal passenger proteins are members of a group of proteins that move from centromeres to the spindle midzone during mitosis. INCENP (Inner Centromere Protein) is a chromosomal passenger protein with an essential role in mitosis and meiosis. It is a complex highly basic multidomain protein that is dynamically translocated from metaphase chromosomes to the spindle midzone during or just prior to anaphase. Some INCENP transfers to the equatorial cortex before formation of the cleavage furrow. Ultimately, it is discarded in the midbody at the completion of cytokinesis. INCENP, in complex with the passenger proteins aurora B kinase and survivin, acts at multiple points during mitosis. Studies in knockout mice established INCENP as essential for mouse development and viability. Loss of INCENP results in chromosome segregation defects and failures in cytokinesis. Targeting of survivin to its centromeric and central spindle locations during mitosis is dependent on INCENP. Direct binding of INCENP to beta tubulin has been demonstrated. Interactions of INCENP with heterochromatin protein HP1Hsa alpha and histone H2A.Z were also reported. INCENP levels are increased in several human cancer lines.
Expand 1 Items
Anti-TIMP1 Rabbit Polyclonal Antibody
Supplier: Prosci
Tissue inhibitor of metalloproteinases 1 (TIMP1) and Tissue inhibitor of metalloproteinases 2 (TIMP 2) have similar properties, specifically in inhibiting enzymes of the matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP1 forms a complex of 1:1 stoichiometry with activated interstitial collagenases, activated stromelysin, active form of 72kDa Type IV collagenase (also known as MMP2 or gelatinase A), and latent and active forms of 92kDa Type IV collagenase (also known as MMP0 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumour cells and normal placental trophoblast cells. TIMP1 is produced in low (pg/mL) levels by most cell types. Treatment of cells with the phorbol ester TPA stimulates production of TIMP1 in some cell types, but the low protein levels produced often require concentration of cell culture media to visualize the bands by Western Blotting.
Expand 1 Items
Celestron StarSense Explorer DX 130AZ
Supplier: Celestron International
StarSense Explorer is ideal for beginners thanks to the app’s user-friendly interface and detailed tutorials.
Expand 1 Items
Purifier® Class I Safety Enclosures, Labconco®
Supplier: Labconco
These enclosures provide practical, economical protection of operator and environment for applications involving biohazardous material and toxic particulates
Expand 12 Items
UVP GelStudio and GelStudio touch 12 MP Imaging Systems, Analytik Jena
Supplier: Analytik Jena CA
The UVP GelStudio touch and non-touch are gel documentation systems which use a 12 MP camera for high sensitivity imaging for DNA gels, protein gels, Coomassie Blue, GelGreen, SYBR Green and a wide range of genomic applications.
Expand 2 Items
Axygen® Mag Plant Genomic DNA Kit, Corning
Supplier: Corning
The AxyPrep Mag Plant genomic DNA kit is a magnetic beads based purification system that allows rapid and reliable isolation of high quality gDNA from multiple plant samples
Expand 3 Items
Bioquell Qube, Isolator with Integrated Bio-decontamination
Supplier: Eco Lab
The Bioquell Qube is a configurable isolator integrated with Bioquell’s Hydrogen Peroxide Vapor technology. From its unique design to customizable features, the Bioquell Qube helps ensure your aseptic workspace needs are met for a productive working environment.
Expand 1 Items
CytoFLEX SRT Bench Top Cell Sorter, Beckman Coulter
Supplier: Beckman Coulter
If you need an approachable instrument for sorting multiple populations to generate high quality material for downstream assays, the CytoFLEX SRT benchtop cell sorter is quick to learn and easy to operate. This extension of the CytoFLEX platform is built on the same optical features as the flow cytometer, but equally important, it continues to adhere to the principles that made multicolor applications accessible to many biomedical research, core research, pharma and biotechs.
Expand 7 Items
Purifier® HEPA-Filtered Enclosures, Labconco®
Supplier: Labconco
These enclosures provide practical, economical protection of operator and environment for applications that generate fine dusts or aerosols but do not provide product protection
Expand 12 Items
Celestron StarSense Explorer DX 102AZ Telescope
Supplier: Celestron International
StarSense Explorer is ideal for beginners thanks to the app’s user-friendly interface and detailed tutorials.
Expand 1 Items
Quick-RNA™ Plus Kits, Zymo Research
Supplier: Zymo Research
RNA from any sample (cells, tissues, biological fluids and more).
Expand 3 Items
OmniTemplate™ for Single Tube Preparation of PCR Template DNA, G-Biosciences
Supplier: G-Biosciences
G-Biosciences' OmniTemplate™ is specifically designed for the rapid isolation of a DNA template for polymerase chain reaction (PCR) analysis from mammalian tissue samples, blood and cell cultures
Expand 1 Items
MPure Plant DNA Extraction Kit, MP Biomedicals
Supplier: MP Biomedicals
MPure Plant DNA Extraction Kit is used with the MPure-12 instrument for extraction of genomic DNA from plant (leaf, seeds and spores) and fungal tissues. Up to 100 mg of tissue can be used for purification.
Expand 2 Items
FilterMate™ Portable Exhausters, Labconco®
Supplier: Labconco
Portable exhausters for use with XPert™ balance enclosures and weigh boxes, Precise™ HEPA-filtered glove boxes, and Protector™ XVS ventilation stations, demonstration hoods, and workstations. Exhausters use carbon and/or HEPA filters to remove hazardous powders, particulates, or vapors from the exhaust air stream, returning filtered air to the environment. No ducting to the outside is required.
Expand 15 Items
E.Z.N.A.® FastFilter Plasmid DNA Mini Kits, Omega Bio-tek
Supplier: Omega Bio-Tek
Isolate plasmid DNA from up to 5 ml culture in 9 minutes utilizing an innovative lysate clearance column.
Expand 3 Items
XPert™ Balance Enclosures, Labconco®
Supplier: Labconco
These low-profile enclosures provide user protection by keeping powders, particulates, and fumes contained during weighing procedures
Expand 75 Items
Zymo-Seq™ ATAC Library Kit
Supplier: Zymo Research
Zymo-Seq™ ATAC library kit provides a simple and streamlined workflow for assay for transposase accessible chromatin with high throughput sequencing (ATAC-Seq) library preparation from mammalian cell and tissue input.
Expand 1 Items
Mag-Bind® Environmental DNA 96 Kit
Supplier: Omega Bio-Tek
Isolate DNA from soil and water samples using magnetic beads.
Expand 2 Items
Rapid DNA Template Prep™ for Rapid Preparation of DNA Template for Small Samples, G-Biosciences
Supplier: G-Biosciences
G-Biosciences' Rapid DNA Template Prep™ kit is suitable for the preparation of DNA templates from blood, cells, animal tissues and plant samples.
Expand 2 Items
E.Z.N.A.® Tissue DNA Extraction Systems, Omega Bio-tek
Supplier: Omega Bio-Tek
Omega Bio-tek® provides multiple options for genomic, viral, and mitochondrial DNA extraction from cultured cells, buccal swabs, mouse tail snips, whole blood, buffy coat, and a variety of animal tissue