16461 Results for: "1,2-dibenzoylmethane"
Corrected to: 1,2-dibenzylethane
Anti-NLRP12 Rabbit Polyclonal Antibody (Cy7®)
Supplier: Bioss
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Expand 1 Items
Anti-NLRP12 Rabbit Polyclonal Antibody (Cy3®)
Supplier: Bioss
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Expand 1 Items
EcoSense ODO200 Optical DO and Temperature Meters, YSI
Supplier: YSI
The ODO200 is designed for quick, accurate results in an economical platform. The ability to measure DO optically along with temperature, in a simple, compact handheld allows the instrument to be used across multiple application sampling strategies in the field.
Expand 4 Items
Now Available: Our latest edition of elements!
Unlock innovation! Packed with products from both our leading suppliers and our exclusive Avantor® brands.
Ultimate Plasticware Set, Eisco Scientific
Supplier: Wards
Durable and shatterproof 15 piece plastic labware set.
Expand 1 Items
Anti-TSPAN12 Rabbit Polyclonal Antibody
Supplier: Prosci
TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.
Expand 1 Items
Pierce™ EZ-Link™ Plus Activated Peroxidase, Thermo Scientific
Supplier: Thermo Scientific
Activated peroxidase is an amine-reactive form of horseradish peroxidase (HRP) that provides coupling efficiencies of greater than 95% with antibodies and other proteins.
Expand 3 Items
Anti-CASP1 Rat Monoclonal Antibody
Supplier: Enzo Life Sciences
Capases are a highly conserved family of cysteine proteases and are synthesized as inactive zymogens, which are cleaved at Asp-x sites during apoptosis, generating large and small subunits that heterodimerize to form the active enzyme. Caspase-1 is a member of the ICE/CED-3 family of caspases and is detected in the pro-form as a protein of 45 kDa.
Caspase-1 generates the bioactive form of the pro-inflammatory cytokine IL-1β from its biologically inactive precursor. Overexpression of caspase-1 in cells induces apoptosis, which can be inhibited by cytokine response modifier A (CrmA). Caspase-1 mRNA is predominantly expressed in the spleen and lung and to a lesser extent in skeletal muscle, kidney, testis and heart and within these tissues macrophages preferentially express caspase-1. Caspase-1 deficient mice have no gross abnormalities, however, macrophages from caspase-1-deficient mice are defective in IL-β processing and release.
Expand 1 Items
PharmaRoam7 Mobile, Vaccine and Pharmaceutical Refrigerator, Roemer Industries
Supplier: ROEMER INDUSTRIES, INC.
PharmaRoam7 is a medical-grade, countertop refrigerator that has optional accessories such as battery power and data management. Designed to transport vaccines and pharmaceuticals, units function as refrigerators down to 1 °C and run on a battery while on the move. These units can be secured with a padlock, have a handle on the top and can be stacked with stacking corners. Excellent for disaster preparedness to store temperature sensitive products when the electrical power supply is not reliable or dependable.
Expand 3 Items
Anti-KCNK12 Rabbit Polyclonal Antibody
Supplier: Prosci
KCNK12 Antibody: KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity. Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells. KCNK12 is expressed mainly in the brain and lung, but also observed in the kidneys, heart and skeletal muscle. KCNK12 is closely related to KCNK13 (58% identity at the amino acid level), but could not yet been functionally expressed in vitro and may require other proteins to become active.
Expand 1 Items
DIBMA Screening Kit, HEPES
Supplier: CUBE BIOTECH
DIBMA stands for diisobutylene maleic acid copolymer, and is an extensively researched polymer. The fundamental properties of DIBMA include the absence of light absorption at a wavelength >250 nm, a crucial factor for protein detection via absorbance, and a high resistance to divalent cations.
Expand 1 Items
Hettich ROTINA 380 General Purpose Benchtop Centrifuges, Hettich Lab Technology
Supplier: HETTICH INSTRUMENTS
The Hettich Lab Technology ROTINA 380 benchtop centrifuge series delivers versatility, capacity and performance in a compact footprint.
Expand 2 Items
Ni Sepharose™ excel Immobilised Metal Ion Affinity Chromatography (IMAC) Media, Cytiva
Supplier: Cytiva
Ni Sepharose™ excel is an IMAC medium pre-charged with nickel ions very strongly bound to a chelating ligand. Samples that usually cause stripping of metal ions can, therefore, be loaded to the medium. Ni Sepharose™ excel is designed primarily for capture and purification of histidine-tagged proteins secreted into cell culture supernatants from eukaryotic cells such as insect cells or CHO cells.
Expand 5 Items
CryoPlus AutoFill Cryogenic Storage Systems, Thermo Scientific
Supplier: Thermo Fisher Scientific
Our CryoPlus LN2 storage systems provide precise and accurate control over all parameters without complicated programming.
Expand 3 Items
Capto™ MMC Multimodal Chromatography Media
Supplier: Cytiva
Capto MMC is a multimodal cation exchanger with a different selectivity, compared with traditional ion exchangers.
Expand 2 Items
Anti-TNFSF12 Rabbit Polyclonal Antibody
Supplier: Prosci
TWEAK Antibody: TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.
Expand 1 Items
Anti-S100A8 & S100A9 Mouse Monoclonal Antibody (CF640R) [clone: MAC387]
Supplier: Biotium
Calgranulin B / MRP-8/-14 / MAC 387Monoclonal antibody, Clone: MAC387, Host: Mouse, Species reactivity: Monkey, Goat, Baboon, Pig, Dog, Isotype: IgG1, kappa, Conjugate: CF640R, Immunogen: Recognizes L1 molecule, 12kDa alpha/14kDa beta chain, Size: 100ul
Expand 2 Items
Anti-S100A8 & S100A9 Mouse Monoclonal Antibody (CF647) [clone: MAC387]
Supplier: Biotium
Calgranulin B Monoclonal antibody, Clone: MAC387, Host: Mouse, Species: Monkey, Goat, Baboon, Pig, Dog, Isotype: IgG1, K, Conjugate: CF647, Immunogen: Recognizes the L1 or Calprotectin molecule of a 12kDa and 14kDa, Synonyms: MRP-8/-14, Application: IF, IHC, Fc, Size: 500ul
Expand 2 Items
Anti-PRDM12 Rabbit Polyclonal Antibody
Supplier: Prosci
PRDM12 belongs to PR-domain family which are involved in human cancers in an unusual yin-yang fashion. Two products are normally produced from a PR-domain family member which differ by the presence or absence of the PR domain; the PR-plus product is disrupted or underexpressed whereas the PR-minus product is present or overexpressed in cancer cells. This imbalance in the amount of the two products, a result of either genetic or epigenetic events, appears to be an important cause of malignancy. PRDM12 may have a potential role in the pathogenesis of chronic myeloid leukaemia with derivative chromosome 9 deletion.
Expand 1 Items
VACUETTE® Safety Blood Collection Set with Blood Culture Holder, Greiner Bio-One
Supplier: Greiner Bio-One
The VACUETTE® Safety Blood Collection Set with Blood Culture Holder is used in routine venipuncture procedures.
Expand 2 Items
Sartoclear Dynamics® Lab V Clarification and Sterile Filtration Kits, Sartorius
Supplier: Sartorius
Sartoclear Dynamics® Lab products are filtration kits designed for the clarification and sterile filtration of up to 1000 ml mammalian cell cultures.
Expand 3 Items
Anti-NLRP12 Rabbit Polyclonal Antibody (Cy5.5®)
Supplier: Bioss
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Expand 1 Items
Anti-NLRP12 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
Supplier: Bioss
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Expand 1 Items
Anti-S100A8 & S100A9 Mouse Monoclonal Antibody (CF488A) [clone: MAC387]
Supplier: Biotium
Calgranulin B / MRP-8/-14 Monoclonal antibody, Clone: MAC387, Host: Mouse, Species reactivity: Monkey, Goat, Baboon, Pig, Dog, Cow, Cat, Rat, Human, Isotype: IgG1, K, Conjugate: CF488A, Synonyms: MAC 387 / S100A8/A9 / Macrophage Ag, Size: 500 uL
Expand 2 Items
Anti-S100A8 & S100A9 Mouse Monoclonal Antibody (CF568) [clone: MAC387]
Supplier: Biotium
Calgranulin B / MRP-8/-14 Monoclonal antibody, Clone: MAC387, Host: Mouse, Species reactivity: Monkey, Goat, Baboon, Pig, Dog, Cow, Cat, Rat, Human, Isotype: IgG1, K, Conjugate: CF568, Synonyms: MAC 387 / S100A8/A9 / Macrophage Ag, Size: 100uL
Expand 2 Items
Single Cylinder Hand Truck with Hoist Ring, Justrite®
Supplier: Justrite
This Single Cylinder Hand Truck with Hoist Ring provides safety when moving and storing of gas cylinders.
Expand 1 Items
Anti-NLRP12 Rabbit Polyclonal Antibody (Cy5®)
Supplier: Bioss
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-kB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
Expand 1 Items
Cooling Bath Circulators, CC-Range, Huber
Supplier: Huber
Refrigeration bath circulators are suitable for controlling the temperature of externally connected applications and thermoregulation of objects directly in the thermostat bath
Expand 1 Items
Nucleic Acid Isolation Kits, illustra™ triplePrep Kit, Cytiva
Supplier: Cytiva
The illustra™ triplePrep Kit is designed for the rapid, simultaneous extraction and isolation of high yield genomic DNA (gDNA), total RNA, and total denatured proteins from undivided animal tissues and mammalian cells. The streamlined workflow reduces the overall number of steps, enabling the preparation of all three analytes in less than one hour.
Expand 1 Items
VWR® Traceable® Digital Thermometer with Recorder Output
Supplier: VWR International
This thermometer’s recorder output jack provides a 1mV signal per degree, which enables it to be used with any chart recorder, strip recorder, or computer that accepts millivolt signals.
Expand 1 Items
Anti-C12ORF5 Rabbit Polyclonal Antibody
Supplier: Prosci
TIGAR Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. Recent studies have demonstrated the ability of p53 to regulate the expression of several proteins involved in glycolysis and oxidative phosphorylation, such as TIGAR, SCO2, and phosphoglycerate mutase. TIGAR is a recently discovered protein that functions to regulate glycolysis and protect cells against oxidative stress. TIGAR is similar in structure to proteins in the phosphoglycerate mutase family, most notably 6-phosphofructo-2-kinase, suggesting TIGAR may function as a fructose bisphosphatase. Expression of TIGAR in transfected cells correlated with an inhibition of glycolysis and decreased levels of reactive oxygen species and p53-induced apoptosis, indicating that TIGAR may act to modulate the apoptotic response to p53, thereby allowing cells to survive mild or transient stresses.