19215 Results for: "(S)-(+)-3,4,7,8-Tetrahydro-8α-methyl-1,6(2H,7H)-naphthalenedione"
Anti-CDH16 Rabbit Polyclonal Antibody
Supplier: Prosci
CDH16 is a member of the cadherin superfamily, which are calcium-dependent, membrane-associated glycoproteins. CDH16 consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
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Rapid Response™ Fentanyl Test Strip (Liquid / Powder), BTNX
Supplier: BTNX INC.
The Rapid Response™ Fentanyl Test Strip (Liquid / Powder) detects fentanyl in suspicious substances on surfaces and liquids from suspicious receptables at a cut-off concentration of 200 ng/mL.
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Purifier® Filtered PCR Enclosures, Labconco®
Supplier: Labconco
Enclosures provide a controlled environment in which to perform polymerase chain reaction (PCR) procedures
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FOCUS: SAFETY - OUT NOW!
Let’s enhance safety by considering personalized protection equipment (PPE) solutions tailored to your team, processes, and products.
Anti-HbBs Mouse Monoclonal Antibody [Clone: 23E5.H6.G6.C1.H7.F7.G9.F6]
Supplier: Rockland Immunochemical
HbS antibodies detect the E6V mutant in the hemoglobin beta subunit. Functional adult hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (α2β2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA2. Hemoglobin S is the predominant hemoglobin in people with sickle cell disease. The alpha chain is normal. The disease-producing mutation exists in the beta chain, giving the molecule the structure, α2βS2. People who have one sickle mutant gene and one normal beta gene have sickle cell trait which is benign. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Perhaps the most significant mutation is the E6V in the beta subunit and the cause of SCD, but other relevant isoforms of Hb are observed. HbS antibody does not react to other forms of Hb. This antibody is ideal for investigators involved in Cardiovascular and developmental biology research.
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Portable Waterproof pH/EC/TDS Meter, Low Range
Supplier: Hanna
Designed to bring simplicity to environmental testing, this pH/EC/TDS Meter is designed specifically for use in manufacturing and environmental testing protocols. The specialized electrode combines 3 sensors in a single rugged probe body featuring a polypropylene body, integrated temperature sensor, and cloth junction.
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Cubis® II Essential Premium Semi-Micro Balances, MCE Series, Standard Versions, Sartorius
Supplier: Sartorius
These MCE series advanced user interface balances have fully customizable hardware, software, and connectivity including touch, scroll, swipe functionality with factory-installed essential weighing applications and diverse QApp packages for optional software extension.
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Analytical Balances, Entris II Basic Advanced, Sartorius
Supplier: Sartorius
Entris® II Basic Advanced analytical balances feature isoCAL, intuitive graphic touch display and 13 built-in applications. Highly accurate results are guaranteed via the monolithic weigh cell technology. High chemical resistance is ensured by using parts made from hard-wearing PBT, stainless steel and glass. Integrated protection systems increase reliability of weighing results: 3 configurable levels determine valid weighing data and ensure only valid data is transferred to external devices.
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Anti-SNCA Mouse Monoclonal Antibody [clone: 4B12]
Supplier: Genetex
The implication of alpha synuclein in neurodegenerative diseases started after the identification of non A beta component of amyloid (NAC peptide) in Alzheimeris disease (AD) brains.There is now a general group of synucleinopathies which implicates alpha synuclein in Lewy body syndromes, Parkinsonis disease, and Alzheimeris disease. Certain missense mutations in the alpha synuclein gene (A53T, A30P) have been linked to the familial Parkinsonis disease (PD). Alpha synuclein is the major component of Lewy bodies and Lewy neuritis in sporadic PD, dementia with Lewy Bodies and Lewy Body variant of AD. Lewy bodies are composed of truncated and phosphorylated intermediate neurofilament proteins, alpha synuclein, ubiquitin and associated enzymes. The synuclein phosphoproteins (15-20 kD) are small highly conserved proteins in vertebrates. The synuclein family includes alpha and beta synucleins and loosely related gamma synuclein and synoretin.The expression is abundant in neurons and typically localized at presynaptic terminals. Antibodies to alpha synuclein provide a specific method to detect Lewy bodies and associated pathological mechanism of PD and AD.
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Anti-FBXO16 Rabbit Polyclonal Antibody
Supplier: Prosci
FBXO16 is a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. FBXO16 belongs to the Fbx class.This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class.
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Rt®-Alumina BOND/CFC Columns (fused silica PLOT), Restek
Supplier: Restek
Restek Rt®-Alumina BOND columns are highly selective for C1 to C5 hydrocarbons and separate all saturated and unsaturated hydrocarbon isomers above ambient temperatures.
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Protector® Airo™ Filtered Fume Hoods, Labconco Corporation
Supplier: Labconco
Fully-featured, energy-efficient fume hoods provide an environmentally-friendly solution to ducted fume hoods while simplifying installation due to their compact footprint.
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XPert™ Filtered Balance Systems, Labconco®
Supplier: Labconco
These portable systems provide user protection by keeping powders and particulates contained during weighing procedures
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Anti-HbBs Mouse Monoclonal Antibody [Clone: 23E5.H6.G6.C1.H7.F7.G9.F6]
Supplier: Rockland Immunochemical
HbS antibodies detect the E6V mutant in the hemoglobin beta subunit. Functional adult hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (α2β2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA2. Hemoglobin S is the predominant hemoglobin in people with sickle cell disease. The alpha chain is normal. The disease-producing mutation exists in the beta chain, giving the molecule the structure, α2βS2. People who have one sickle mutant gene and one normal beta gene have sickle cell trait which is benign. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Perhaps the most significant mutation is the E6V in the beta subunit and the cause of SCD, but other relevant isoforms of Hb are observed. HbS antibody does not react to other forms of Hb. This antibody is ideal for investigators involved in Cardiovascular and developmental biology research.
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Coomassie® brilliant blue R-250 65% (dye basis) protein stain
Supplier: Thermo Scientific
Thermo Scientific Pierce Coomassie Brilliant Blue R-250 is one of the most common forms of coomassie dye, which is a key component of various colorimetric protein gel stains.
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Anti-GRIN2A Rabbit Polyclonal Antibody
Supplier: Prosci
The NMDA receptor (NMDAR) plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.
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Purifier® Class I Safety Enclosures, Labconco®
Supplier: Labconco
These enclosures provide practical, economical protection of operator and environment for applications involving biohazardous material and toxic particulates
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Anti-WNT16 Rabbit Polyclonal Antibody
Supplier: Prosci
WNT proteins are secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT16 contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.
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FilterMate™ Portable Exhausters, Labconco®
Supplier: Labconco
Portable exhausters for use with XPert™ balance enclosures and weigh boxes, Precise™ HEPA-filtered glove boxes, and Protector™ XVS ventilation stations, demonstration hoods, and workstations. Exhausters use carbon and/or HEPA filters to remove hazardous powders, particulates, or vapors from the exhaust air stream, returning filtered air to the environment. No ducting to the outside is required.
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Mag-Bind SeqDTR, Omega Bio-Tek
Supplier: Omega Bio-Tek
Omega Bio-teks Mag-Bind SeqDTR is designed to effective and reliable removal of unincorporated terminators from sequencing reaction. The system combines Omega Bio-teks proprietary chemistry with the reversible nucleic acid-binding properties of paramagnetic beads to eliminate excess nucleotides, primers, salts, and unicorporated dye terminators.
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Anti-GRIN1 Rabbit Polyclonal Antibody
Supplier: Prosci
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.
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Purifier® HEPA-Filtered Enclosures, Labconco®
Supplier: Labconco
These enclosures provide practical, economical protection of operator and environment for applications that generate fine dusts or aerosols but do not provide product protection
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Anti-WNT16 Rabbit Polyclonal Antibody
Supplier: Prosci
WNT proteins are secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT16 contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen.
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ZymoBIOMICS 96 MagBead DNA Kit
Supplier: Zymo Research
Inhibitor-free microbial DNA from any sample validated for microbiome and metagenomic analyses.
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Anti-SUPT16H Rabbit Polyclonal Antibody
Supplier: Prosci
Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is SUPT16H. Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit, the latter of which is the protein encoded by this gene. Sequence Note: The sequence AF152961.1 is a chimeric mRNA clone. Only the SUPT16H region was propagated into this RefSeq record. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
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Anti-GRIN1 Rabbit Polyclonal Antibody
Supplier: Prosci
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.
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Anti-GRIN2B Rabbit Polyclonal Antibody
Supplier: Prosci
The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits (Ishii et al., 1993). Phosphorylation of Tyr1336 is thought to potentiate NMDA receptor-dependent influx of calcium (Takasu et al., 2002) and ischemia may also increase the phosphorylation of this site (Takagi et al., 2003).
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Rapid Response™ Fentanyl Test Strip Kit (Liquid / Powder), BTNX
Supplier: BTNX INC.
The Rapid Response™ Fentanyl (FYL) forensic test kit is a lateral flow chromatographic immunoassay for the qualitative detection of fentanyl in liquid and powder substances at the cut-off concentration of 200 ng/ml.
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Anti-GRIN1 Rabbit Polyclonal Antibody
Supplier: Prosci
NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.
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FreeZone® Triad® Benchtop Freeze Dryers, Labconco®
Supplier: Labconco
FreeZone® Triad® Benchtop Freeze Dryers are designed for multiple types of lyophilization: flask, bulk and stoppering vials. With the ability to freeze dry samples in so many different forms, the Triad’s versatility and compact design make it perfect for busy labs. Now with Lyo-Works™ OS the Triad is smarter than ever, making freeze drying even challenging samples easy.
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Cubis® II Advanced Premium Precision Laboratory Balances, Automatic, Standard Version, Sartorius
Supplier: Sartorius
These MCA series advanced user interface laboratory balances have fully customizable hardware, software, and connectivity including touch, scroll, swipe functionality with factory-installed essential weighing applications and diverse QApp packages for optional software extension.