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Specifications
- Gene ID:3565 P05112
- Protease-free:Y
- Protein Function:Cytokines and Growth Factors
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Conjugation:Unconjugated
- Size:20 μg
- Storage conditions:Store at –20 °C prior to reconstitution.
- Endotoxin content:>0.1 ng/μg
- Biological activity:Biological Activity tests can vary. Please refer to the Product CoA for information.
- Form:Lyophilized
- Reconstitution instructions:Reconstitution instructions can vary. Please refer to the product CoA for info.
- Protein synonyms:B-cell Stimulating Factor (BSF-1)|BCGF|BCDF|Interleukin-4
- Protein/peptide name:IL-4
- Purity:0.98
- Molecular weight:15.1 kDa
- Sequence:MHKCDITLQE IIKTLNSLTE QKTLCTELTV TDIFAASKNT TEKETFCRAA TVLRQFYSHH EKDTRCLGAT AQQFHRHKQL IRFLKRLDRN LWGLAGLNSC PVKEANQSTL ENFLERLKTI MREKYSKCSS
- Endotoxin level:Low
- Formulation:Formulation can vary. Please refer to product CoA for information.
- Shipping temperature:Ambient
- Cat. no.:10779-606
- Origin:USA
- Supplier No.:200-04-20UG
Specifications
About this item
IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Human IL-4 is a 15.1 kDa globular protein containing 130 amino acid residues.
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