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Specifications
- Antibody type:Primary
- Antigen name:Integrin beta 1
- Clonality:Monoclonal
- Clone:4B7
- Gene ID:3688
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Antigen symbol:ITGB1
- Conjugation:Unconjugated
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- ImmunoPrecipitation:Yes
- Size:100 μl
- Antigen synonyms:FNRB|integrin VLA-4 beta subunit|VLA-BETA|VLAB|VLA-4 subunit beta|CD29|beta polypeptide|MDF2|MSK12|GPIIA|Fibronectin receptor subunit beta|very late activation protein
- Storage buffer:Phosphate-buffered saline
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:1 mg/ml
- Immunogen:Human ocular melanoma cell line V + B2
- Tested applications:Fluorescence-Activated Cell Sorting
- Purification:Protein A purified
- Cat. no.:89360-748
- Supplier No.:GTX20035
Specifications
About this item
Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6, also known as CD49a, CD49b, CD49c, CD49d, CD49e, and CD49f, respectively) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. The clustering of integrins on a cell surface leads to the formation of focal contacts. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.
FACS: Use at an assay dependent dilution. IF: 1/125 - 1/250. IHC-P: 1/125 - 1/250. IP: Use at 2?g/mg of lysate. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: ITGB1
Clonality: Monoclonal
Clone: 4B7
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human