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Specifications
- Antibody type:Primary
- Antigen name:Neural Cell Adhesion Molecule 1
- Clonality:Monoclonal
- Clone:MEM-188
- Gene ID:4684
- Host:Mouse
- Isotype:IgG2a
- Reactivity:Human
- Antigen symbol:NCAM1
- Conjugation:PE (Phycoerythrin)
- Flow cytometry:Yes
- Size:100 test
- Antigen synonyms:NCAM|MSK39|CD56
- Storage buffer:Preservative: 15mM Sodium Azide. Constituents: PBS, 0.2% BSA. pH 7.4
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Immunogen:Tissue / cell preparation (KG-1 human acute myelogenous leukaemia cell line).
- Tested applications:Fluorescence-Activated Cell Sorting
- Cat. no.:89360-446
- Supplier No.:GTX18277
Specifications
About this item
NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig)-like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins. NCAM is expressed on most neuroectodermal derived cell lines, tissues and neoplasm such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma.
FACS: Use at an assay dependent dilution. Designed for analysis of human blood cells using 20ul reagent per 100ul whole blood. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: NCAM1
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human