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Specifications
- Antibody type:Primary
- Antigen name:Phosphodiesterase 1A calmodulin-dependent
- Clonality:Polyclonal
- Gene ID:5136
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:PDE1A
- Conjugation:Unconjugated
- ImmunoPrecipitation:Yes
- Size:100 μg
- Western blot:Yes
- Antigen synonyms:calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase|3',5' cyclic nucleotide phosphodiesterase|phosphodiesterase-1A|MGC26303|calmodulin-dependent|HSPDE1A|PDE1A|HCAM1|calmodulin-dependent phosphodiesterase|phosphodiesterase 1A
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:0.65 mg/ml
- Immunogen:Synthetic peptides (conserved sequence near the N-terminal) unique to PDE1A family members.
- Tested applications:IP, WB
- Purification:Immunogen affinity purified
- Cat. no.:89367-328
- Supplier No.:GTX14599
Specifications
About this item
Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodieterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-11) based on their kinetic properties and inhibition to various pharmacological agents. Three different PDE1 genes have been identified (PDE1A, B, and C). PDE1A and PDE1B have higher affinity for cGMP than for cAMP, whereas PDE1C has high affinity for both cAMP and cGMP. The PDE1A gene family includes various proteins that differ from each other at amino and carboxy termini of the protein. There are three novel PDE1A variants so far identified (PDE1A1; PDE1A3 and PD1A5), PDE1A5 encodes a 519 residue protein , which is different from PDE1A1 by insertion of 14 amino acid residues at the carboxy terminal and is also different from PDE1A3 by a divergent at N-terminus. The tissue distribution of PDE1A is different from other PDE1 gene family members. In testis PDE1A is highly expressed but in different stages of developing germ cells.
IP: Use at a dilution of 1/200. WB: Use at a dilution of 1/250 - 1/500. Predicted molecular weight: 61 kDa. This antibody labels multiple bands in 65-72 kDa range all believed to be various PDE1A variants expressed in various rat tissues. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: PDE1A
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human