To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:
- • State issued document with your organization's Federal Tax ID Number
- • State issued document with your organization's Resale Tax ID Number
- • City or County issued Business License
- • State Department of Health Services License
- • Any other ID issued by the State that includes the business name & address
* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.
Specifications
- Antibody type:Primary
- Antigen name:Caspase 1
- Clonality:Monoclonal
- Clone:14F468
- Gene ID:834
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Antigen symbol:CASP1
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:50 μg
- Western blot:Yes
- Antigen synonyms:interleukin 1-B converting enzyme|ICE|IL1B-convertase|P45|apoptosis-related cysteine peptidase interleukin 1|IL1BC|beta|IL-1 beta-converting enzyme|caspase 1|interleukin 1|convertase|caspase-1|CASP1 nirs variant 1
- Amino acid number:371 to 390
- Storage buffer:Preservative: 0.05% Sodium Azide; Constituents: 0.2% Gelatin, PBS
- Sequence:RKVRFSFEQPDGRAQMPTTE
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:0.5 mg/ml
- Immunogen:Synthetic peptide: RKVRFSFEQPDGRAQMPTTE , corresponding to amino acids 371-390 of Human Caspase 1.
- Tested applications:IHC-P
- Purification:Protein G purified
- Cat. no.:89359-980
- Supplier No.:GTX14367
Specifications
About this item
Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase 1 is similar to the cell death gene CED3 of C. elegans and regulates multiple proinflammatory cytokines, including Interleukin 1b and interferon-gamma-inducing factor. Caspase 1 plays a role in down stream of Caspase 8 which is involved in Fas-mediated apoptosis.
WB: Use at a concentration of 0.5 - 2 ?g/ml. Detects a band of approximately 45 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: CASP1
Clonality: Monoclonal
Clone: 14F468
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype:
Reactivity: Human