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Specifications
- Antibody type:Primary
- Antigen name:Brain Natriuretic Peptide
- Clonality:Monoclonal
- Clone:24E11
- Gene ID:4879
- Host:Mouse
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:NPPB
- Conjugation:Unconjugated
- ELISA:Yes
- Size:200μg
- Western blot:Yes
- Antigen synonyms:BNP|natriuretic peptide B
- Storage buffer:Phosphate buffered saline, pH 7.4, containing 0.01% sodium azide
- Storage temperature:Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. We recommend to parafilm vials during storage to prevent evaporation of buffer.
- Concentration:8.8 mg/ml
- Immunogen:Synthetic peptide: RGHRKMVLYTLRAPR, corresponding to amino acids 61 - 76 of Human proBNP.
- Tested applications:ELISA, WB
- Purification:Protein A purified
- Cat. no.:89350-872
- Supplier No.:GTX13123
Specifications
About this item
In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa ""signal"" peptide and a 108 aa pro-BNP. Proteolytic digestion of pro-BNP results in formation of 76 aa amino-terminal NT-proBNP and biologically active 32 aa BNP hormone molecule. Both proBNP and NTproBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiac complications at patients with heart failure.
For ELISA: Use at an assay dependent dilution. For WB: Use at an assay dependent dilution. Can be paired for ELISA with with GTX13115 Mouse monoclonal [15F11] to proBNP. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.
Type: Primary
Antigen: NPPB
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Human