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Specifications
- Antibody type:Primary
- Antigen name:Superoxide dismutase 2, mitochondrial
- Clonality:Polyclonal
- Gene ID:6648
- Host:Goat
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:SOD2
- Conjugation:Unconjugated
- Size:50 μg
- Western blot:Yes
- Antigen synonyms:mangano-superoxide dismutase|MVCD6|manganese-containing superoxide dismutase|IPO-B|indophenoloxidase B|Mn-SOD|IPOB|superoxide dismutase|MNSOD|manganese superoxide dismutase|Mn superoxide dismutase
- Storage buffer:Preservative: 0.1% Sodium Azide; Constituents: PBS. pH 7.2
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Concentration:1 mg/ml
- Immunogen:Synthetic peptide corresponding to a portion of MnSOD encoded within exon 5 (Human).
- Tested applications:WB
- Purification:Immunogen affinity purified
- Cat. no.:89358-932
- Supplier No.:GTX11889
Specifications
About this item
Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells. They are: extracellular SOD (EC SOD), copper and zinc-containing SOD (Cu/Zn SOD) and manganese-containing SOD (Mn SOD). The Cu/Zn form contains Cu and Zn ions and exists as a 32 kDa dimer in the cytosol. Mn SOD is an 80 kDa tetramer that contains Mn ion and resides in the mitochondrial matrix. Mn SOD is a tumor necrosis factor (TNF)-inducible enzyme that protects cells from TNF-mediated apoptosis via superoxide anion detoxification and the subsequent regulation of apoptosis through cytochrome c release and the modulation of the redox state of the mitochondria. Mn SOD has also been shown to be a tumor suppressor in human breast cancer. Overexpression of this enzyme protects neurons from NMDA- and nitric oxide-induced neurotoxicity.
WB: Use at a dilution of 1/1000 - 1/4000. Detects a band of approximately 23 kDa. In some cases, the antibody may be diluted further than indicated. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: SOD2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Goat
Isotype: IgG
Reactivity: Human