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Specifications
- Antibody type:Primary
- Antigen name:Human Claudin 18.2
- Clonality:Monoclonal
- Clone:126C1
- Host:Rabbit
- Isotype:IgG
- Conjugation:Unconjugated
- ELISA:Yes
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:40 μg
- Cross adsorption:No
- Form:Liquid
- Storage buffer:Supplied in PBS, pH 7.4, containing 0.02% ProClin300
- Storage temperature:The product remains stable up to 1 year at −20 °C from date of receipt. Avoid repeated freezing and thawing cycles
- Concentration:1.5 mg/ml
- Immunogen:Recombinant Human Claudin 18.2 Protein and DNA
- Cat. no.:77007-592
- Packaging:Vial
Specifications
About this item
Claudin-18 is a protein that in humans is encoded by the CLDN18 gene. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. The expression of isoform A2 (CLDN18.2) is restricted to the stomach mucosa where it is predominantly observed in the epithelial cells of the pit region and the base of the gastric glands including exocrine and endocrine cells (at protein level). However, CLDN18.2 is highly expressed in certain primary malignant tumors, such as gastric cancer (GC), breast cancer, colon cancer and liver cancer. CLDN18.2 is expressed in 50 - 70% of primary gastric adenocarcinomas and their metastases, thus it is considered a promising candidate for targeted gastric cancer therapy. Therapeutic antibodies against Claudin 18.2 have great therapeutic potential and very low toxicity.
- High specificity
- High affinity
- High stability
GenScript offers highly specific monoclonal and polyclonal primary antibodies. These primary antibodies are validated for multiple applications, including Sandwich ELISA and western blot.
Type: Primary
Antigen: Human Claudin 18.2
Clonality: Monoclonal
Clone: 126C1
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: