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Specifications
- Antibody type:Primary
- Antigen name:PDCD4
- Clonality:Polyclonal
- Gene ID:Q53EL6
- Host:Rabbit
- Antigen symbol:PDCD4
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Size:100 µL
- Western blot:Yes
- Form:Liquid (sterile filtered)
- Antigen synonyms:Death up-regulated gene protein antibody, Dug antibody, H731 antibody, Ma3 antibody, Neoplastic transformation inhibitor antibody, Neoplastic transformation inhibitor protein antibody, Nuclear antigen H731 antibody
- Storage buffer:0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- Molecular weight:52
- Shipping temperature:Wet Ice
- Purification:Affinity Purified
- Cat. no.:76309-348
Specifications
About this item
This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphorylation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun. All Rockland Immunochemical’s RFP antibodies are affinity-purified to assure both high affinity and specificity. Rigorous quality control testing ensures that the finished product meets or exceeds out high standards for optimum performance in your assays.
Type: Primary
Antigen: PDCD4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: human, mouse, rat, Xenopus