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Specifications
- Antibody type:Primary
- Antigen name:Tumor necrosis factor receptor superfamily member 16
- Clonality:Monoclonal
- Clone:8J2
- Gene ID:NGFR
- Host:Mouse
- Isotype:IgG2a
- Reactivity:Human,Rat,Mouse
- Antigen symbol:TNR16
- Flow cytometry:Yes
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:50 µg
- Form:Liquid
- Antigen synonyms:Low affinity neurotrophin receptor p75NTR|NGF receptor|p75 ICD|Gp80-LNGFR|Low-affinity nerve growth factor receptor
- Storage temperature:Liquid antibody is shipped cold. Upon arrival, spin vial briefly, divide into aliquots and store at -20° C for long-term storage. Store at 2…8° C short-term (up to 4 weeks) with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles.
- Shipping temperature:2…8° C
- Immunogen:Recombinant extracellular domain (amino acids 29-250) of human NGFR/p75NTR protein with N-terminal His-tag.
- Purification:Protein A purified
- Cat. no.:76334-030
Specifications
About this item
p75NTR (CD271) was originally discovered as a low affinity nerve growth factor receptor (NGFR). Later it was found that it was the receptor for all neurotrophins, including NGF, BDNF, NT3 and NT4/5. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. Recent research proposes the extracellular domain of p75NTR as a biomarker for monitoring the progression of motor neuron disease (MND), also known as Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's Disease. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3.
Applications: Immunocytochemistry: 1-5 ug/mL. Light fixation only, or unfixed works best. Epitope is sensitive to fixation.
Flow Cytometry: 5-20 ug/mL.
Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: TNR16
Clonality: Monoclonal
Clone: 8J2
Conjugation: Atto488
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human, mouse and rat