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Specifications
- Gene ID:192199
- Protein/peptide type:Recombinant
- Source:CHO cells
- Species:Mouse
- Conjugation:Unconjugated
- Size:50 µg
- Biological activity:R-Spondin-1 enhances BMP-2-mediated differentiation of MC3T3-E1 cells.
- Protein synonyms:Roof plate-specific Spondin-1|RSPO1
- Protein/peptide name:R-Spondin-1
- Purity:95%
- Molecular weight:27 kDa
- Sequence:SRGIKGKRQR RISAEGSQAC AKGCELCSEV NGCLKCSPKL FILLERNDIR QVGVCLPSCP PGYFDARNPD MNKCIKCKIE HCEACFSHNF CTKCQEGLYL HKGRCYPACP EGSTAANSTM ECGSPAQCEM SEWSPWGPCS KKRKLCGFRK GSEERTRRVL HAPGGDHTTC SDTKETRKCT VRRTPCPEGQ KRRKGGQGRR ENANRHPARK NSKEPGSNSR RHKGQQQPQP GTTGPLTSVG PTWAQ
- Endotoxin level:low
- Formulation:Lyophilized
- Shipping temperature:Ambient
- Cat. no.:76303-960
Specifications
About this item
R-Spondin-1 (Rspo-1) belongs to the (Rspo) family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing the furin-like and thrombospondin structural domains. Rspo-1 is expressed in certain areas of the developing central nervous system, as well as in the adrenal glands, ovary, testis, thyroid, and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex in a manner that stimulates the Wnt/beta-catenin signaling pathway. Recombinant Murine R-Spondin-1 is a 27.1 kDa protein consisting of 245 amino acid residues. Due to glycosylation, R-Spondin-1 migrates at an apparent molecular weight of approximately 40.0 kDa by SDS-PAGE analysis under reducing conditions.