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Specifications
- Animal-free:Y
- Gene ID:50616
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Conjugation:Unconjugated
- Size:50 µg
- Biological activity:Assay #1: Determined by its ability to activate STAT following receptor ligand interaction. Assay #2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED50 for this effect is 0.7- 1.0 ng/ml.
- Protein synonyms:IL-TIF|Cytokine ZCYTO18|Interleukin-22
- Protein/peptide name:IL-22
- Purity:98%
- Molecular weight:33.6 kDa
- Sequence:MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI
- Endotoxin level:low
- Formulation:Lyophilized
- Shipping temperature:Ambient
- Cat. no.:76303-794
Specifications
About this item
IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10Rbeta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant Human IL-22 is a 33.6 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.