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Specifications
- Animal-free:Y
- Gene ID:5155
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Conjugation:Unconjugated
- Size:50 µg
- Biological activity:Determined by the dose-dependent stimulation of the proliferation of Balb/c 3T3 cells. The expected ED50 for this effect is 1.0-3.0 ng/ml.
- Protein synonyms:Osteosarcoma-derived Growth Factor (ODGF)|Platelet-Derived Growth Factor-BB|Glioma-derived growth factor (GDGF)
- Protein/peptide name:PDGF-BB
- Purity:98%
- Molecular weight:24.3 kDa
- Sequence:SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT
- Endotoxin level:low
- Formulation:Lyophilized
- Shipping temperature:Ambient
- Cat. no.:76303-584
Specifications
About this item
- Animal-free
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two beta chains (218 total amino acids).
Supplier: VWR International
214,30 $ to 2 349,04 $