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Specifications
- Antibody type:Primary
- Antigen name:telomeric repeat binding factor 2
- Clonality:Polyclonal
- Gene ID:Q15554
- Host:Rabbit
- Isotype:IgG
- Reactivity:Human
- Antigen symbol:TERF2
- Conjugation:Unconjugated
- ELISA:Yes
- ImmunoChemistry:Yes
- Size:0.1 mg
- Western blot:Yes
- Cross adsorption:No
- Form:Liquid
- Antigen synonyms:TERF2
- Storage buffer:TERF2 Antibody is supplied in PBS containing 0.02% sodium azide.
- Molecular weight:Predicted: 60 kDa Observed: 69 kDa
- Storage temperature:TERF2 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year.
- Concentration:1 mg/mL
- Shipping temperature:4 °C
- Immunogen:TERF2 antibody was raised against a 17 amino acid peptide near the amino terminus of human TERF2. The immunogen is located within the first 50 amino acids of TERF2.
- Purification:TERF2 antibody is affinity chromatography purified via peptide column.
- Cat. no.:10126-720
- Supplier No.:7727
Specifications
About this item
The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1). TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2). TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3). TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5).
Type: Primary
Antigen: TERF2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human