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Specifications
- Gene ID:3479 P05019
- Protease-free:Y
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Conjugation:Unconjugated
- Size:1 mg
- Storage conditions:Store at –20 °C prior to reconstitution.
- Endotoxin content:Endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
- Biological activity:Biological Activity tests can vary. Please refer to the Product CoA for information.
- Form:Lyophilized
- Cross reactivity:Monkey, Mouse, Human, Leech, Rat, Human + Mouse, Human + Monkey
- Reconstitution instructions:Reconstitution instructions can vary. Please refer to the product CoA for info.
- Protein synonyms:Long R3 IGF-I|IGF-IA|Insulin-like Growth Factor-I|Somatamedin C
- Protein/peptide name:IGF-I
- Purity:0.98
- Molecular weight:9.1 kDa
- Sequence:MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
- Endotoxin level:Low
- Formulation:Formulation can vary. Please refer to product CoA for information.
- Shipping temperature:Ambient
- Cat. no.:10771-888
- Origin:USA
- Supplier No.:100-11R3-1MG
Specifications
About this item
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro . IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. IGF-I LR3 is a recombinant analog of human IGF-I comprised of the complete IGF-I sequence, with an Arginine substitution for the third position Glutamic acid, and a 13 amino acid length N terminus peptide extension. Specifically engineered for higher biological potency Recombinant Human IGF-I LR3 is a 9.1 kDa, single, non-glycosylated polypeptide chain containing 83 amino acid residues.