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Specifications
- Antibody type:Primary
- Antigen name:EMI1
- Clonality:Monoclonal
- Clone:EMI1/1176
- Gene ID:Unigene ID: 520506
- Host:Mouse
- Isotype:IgG2a kappa
- Reactivity:Human
- Antigen symbol:FBXO5
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:50 μL
- Western blot:Yes
- Storage buffer:PBS, no BSA, no azide
- Concentration:1 mg/mL
- Cat. no.:75925-796
- Supplier No.:BNUM1176-50
Specifications
About this item
This antibody recognizes a 56 kDa protein, which is identified as Early Mitotic Inhibitor-1 (EMI1). It regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Emi1 is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The Emi1 protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, Emi1 is transcriptionally induced by the E2F transcription factor. Emi1 overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of Emi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
Type: Primary
Antigen: FBXO5
Clonality: Monoclonal
Clone: Clone EMI1/1176
Conjugation: Unconjugated, BSA-and azide-free
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: Human