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Specifications
- Antibody type:Primary
- Antigen name:PAX6
- Clonality:Monoclonal
- Clone:PAX6/1166
- Gene ID:Unigene ID: 611376
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Human
- Antigen symbol:PAX6
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- Size:50 μL
- Storage buffer:PBS, no BSA, no azide
- Concentration:1 mg/mL
- Cat. no.:75968-192
- Supplier No.:BNUM1166-50
Specifications
About this item
Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
Type: Primary
Antigen: PAX6
Clonality: Monoclonal
Clone: Clone PAX6/1166
Conjugation: Unconjugated, BSA-and azide-free
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human