About this item
Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
Type: Primary
Antigen: PAX6
Clonality: Monoclonal
Clone: Clone PAX6/1166
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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Specifications
- Catalog No:
- 75968-084
- 75968-086
- Antigen name:
- PAX6
- PAX6
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- PAX6/1166
- PAX6/1166
- Host:
- Mouse
- Mouse
- Gene ID:
- Unigene ID: 611376
- Unigene ID: 611376
- Isotype:
- IgG1 kappa
- IgG1 kappa