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Specifications
- Antibody type:Primary
- Antigen name:Cytochrome C
- Clonality:Monoclonal
- Clone:CTC05
- Gene ID:Unigene ID: 437060
- Host:Mouse
- Isotype:IgG2b kappa
- Reactivity:Drosophila,Frog,Horse,Pigeon,Human,Dog,Rat,Mouse
- Antigen symbol:CYCS
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:50 μL
- Western blot:Yes
- Storage buffer:PBS, no BSA, no azide
- Concentration:1 mg/mL
- Cat. no.:75923-872
- Supplier No.:BNUM0887-50
Specifications
About this item
Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic Cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, Cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of Cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of Cytochrome c and to induce cell death. The release of Cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a Cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.
Type: Primary
Antigen: CYCS
Clonality: Monoclonal
Clone: CTC05
Conjugation: Unconjugated, BSA-and azide-free
Epitope:
Host: Mouse
Reactivity: Dog, Drosophila, Frog, Horse, Human, Mouse, Pigeon, Rat
Isotype: IgG2b, kappa