About this item
Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic Cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, Cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of Cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of Cytochrome c and to induce cell death. The release of Cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a Cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3.
Type: Primary
Antigen: CYCS
Clonality: Monoclonal
Clone: CTC05
Conjugation: Biotin
Epitope:
Host: Mouse
Reactivity: Dog, Drosophila, Frog, Horse, Human, Mouse, Pigeon, Rat
Isotype: IgG2b, kappa
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Specifications
- Catalog No:
- 75923-820
- 75923-822
- Antigen name:
- Cytochrome C
- Cytochrome C
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- CTC05
- CTC05
- Host:
- Mouse
- Mouse
- Gene ID:
- Unigene ID: 437060
- Unigene ID: 437060
- Isotype:
- IgG2b kappa
- IgG2b kappa