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Specifications
- Antibody type:Primary
- Antigen name:MAGE A1
- Clonality:Monoclonal
- Clone:MZ2E/838
- Gene ID:Unigene ID: 72879
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Human
- Antigen symbol:MAGEA1
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:50 μL
- Storage buffer:PBS, no BSA, no azide
- Concentration:1 mg/mL
- Cat. no.:75959-690
- Supplier No.:BNUM0838-50
Specifications
About this item
This antibody recognizes a protein of 42-46 kDa, identified as MAGE-1. This MAb does not cross-react with other members of MAGE-family. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8 T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.
Type: Primary
Antigen: MAGEA1
Clonality: Monoclonal
Clone: Clone MZ2E/838
Conjugation: Unconjugated, BSA-and azide-free
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human