Specifications
- Antibody type:Primary
- Antigen name:Cyclin D1
- Antigen symbol:CCND1
- Clonality:Monoclonal
- Clone:CCND1/809
- Conjugation:Unconjugated
- Host:Mouse
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG2a kappa
- Reactivity:Human
- Western blot:Yes
- Size:50 μL
- Gene ID:Unigene ID: 523852 , 667996
- Storage buffer:PBS, no BSA, no azide
- Concentration:1 mg/mL
- Cat. no.:75924-632
- Supplier No.:BNUM0809-50
Specifications
About this item
This antibody recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Type: Primary
Antigen: CCND1
Clonality: Monoclonal
Clone: Clone CCND1/809
Conjugation: Unconjugated, BSA-and azide-free
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human