About this item
This antibody recognizes a protein of 36 kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
Type: Primary
Antigen: CCND1
Clonality: Monoclonal
Clone: Clone CCND1/809
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human
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Specifications
- Catalog No:
- 75924-996
- 75924-998
- Antigen name:
- Cyclin D1
- Cyclin D1
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- CCND1/809
- CCND1/809
- Host:
- Mouse
- Mouse
- Gene ID:
- Unigene ID: 523852 , 667996
- Unigene ID: 523852 , 667996
- Isotype:
- IgG2a kappa
- IgG2a kappa