About this item
This MAb recognizes a protein of 56.5 kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.
Type: Primary
Antigen: KRT10
Clonality: Monoclonal
Clone: Clone LH2
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human, Mouse
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Specifications
- Catalog No:
- 75916-100
- 75916-098
- Antigen name:
- Cytokeratin 10
- Cytokeratin 10
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Clone:
- LH2
- LH2
- Host:
- Mouse
- Mouse
- Gene ID:
- Unigene ID: 99936
- Unigene ID: 99936
- Isotype:
- IgG1 kappa
- IgG1 kappa