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Specifications
- Antibody type:Primary
- Antigen name:p27 / KIP1
- Clonality:Monoclonal
- Clone:SX53G8
- Gene ID:Unigene ID: 238990
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Monkey,Human,Rat,Mouse
- Antigen symbol:CDKN1B
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:50 μL
- Western blot:Yes
- Storage buffer:PBS, no BSA, no azide
- Concentration:1 mg/mL
- Cat. no.:75967-392
- Supplier No.:BNUM0669-50
Specifications
About this item
This MAb recognizes a 27 kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. In Western blotting of cell lysates from 7 human breast cancer cell lines (ZR75-1, ZR75-30, MCF-7, MDAMB453, T47D, CAL51, 734B), the antibody labels a single band corresponding to p27Kip1. It functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Reportedly, low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma, colon carcinoma, breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, and lymph node metastases in papillary carcinoma of the thyroid, as well as a more aggressive phenotype in carcinoma of the cervix.
Type: Primary
Antigen: CDKN1B
Clonality: Monoclonal
Clone: Clone SX53G8
Conjugation: Unconjugated, BSA-and azide-free
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Monkey, Mouse, Rat