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Specifications
- Antibody type:Primary
- Antigen name:FOXP3
- Clonality:Monoclonal
- Clone:3G3
- Gene ID:Unigene ID: 247700
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Monkey,Human,Mouse
- Antigen symbol:FOXP3
- Conjugation:Unconjugated
- ImmunoFluorescence:Yes
- Size:50 μL
- Storage buffer:PBS, no BSA, no azide
- Concentration:1 mg/mL
- Cat. no.:75927-208
- Supplier No.:BNUM0645-50
Specifications
About this item
This antibody recognizes a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion (amino acids 2-136) of the protein.The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
Type: Primary
Antigen: FOXP3
Clonality: Monoclonal
Clone: Clone 3G3
Conjugation: Unconjugated, BSA-and azide-free
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Monkey, Mouse