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Specifications
- Antibody type:Primary
- Antigen name:Transgelin / SM22-alpha
- Clonality:Monoclonal
- Clone:TAGLN/247
- Gene ID:Unigene ID: 410977
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Pig,Rabbit,Human,Bovine,Mouse
- Antigen symbol:TAGLN
- Conjugation:Unconjugated
- ImmunoFluorescence:Yes
- Size:50 μL
- Storage buffer:PBS, no BSA, no azide
- Concentration:1 mg/mL
- Cat. no.:75977-696
- Supplier No.:BNUM0247-50
Specifications
About this item
This MAb recognizes a 22 kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
Type: Primary
Antigen: TAGLN
Clonality: Monoclonal
Clone: Clone TAGLN/247
Conjugation: Unconjugated, BSA-and azide-free
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Cow, Human, Mouse, Pig, Rabbit