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Specifications
- Antibody type:Primary
- Antigen name:Major Vault Protein
- Clonality:Monoclonal
- Clone:1014
- Gene ID:Unigene ID: 632177
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Human
- Antigen symbol:MVP
- Conjugation:Unconjugated
- ImmunoFluorescence:Yes
- Size:50 μL
- Storage buffer:PBS, no BSA, no azide
- Concentration:1 mg/mL
- Cat. no.:75964-468
- Supplier No.:BNUM0224-50
Specifications
About this item
This antibody recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
Type: Primary
Antigen: MVP
Clonality: Monoclonal
Clone: Clone 1014
Conjugation: Unconjugated, BSA-and azide-free
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human