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Specifications
- Antibody type:Primary
- Antigen name:CD63
- Clonality:Monoclonal
- Clone:NKI-C3
- Gene ID:Unigene ID: 445570
- Host:Mouse
- Isotype:IgG1 kappa
- Reactivity:Human,Mouse
- Antigen symbol:CD63
- Conjugation:Unconjugated
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Size:50 μL
- Western blot:Yes
- Storage buffer:PBS, no BSA, no azide
- Concentration:1 mg/mL
- Cat. no.:75917-306
- Supplier No.:BNUM0186-50
Specifications
About this item
This MAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
Type: Primary
Antigen: CD63
Clonality: Monoclonal
Clone: Clone NKI-C3
Conjugation: Unconjugated, BSA-and azide-free
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human, Mouse